Browse our Research Articles

The central nitrogen-metabolite 2-oxoglutarate directly promotes glutamine synthetase activity by inducing its dodecameric assembly and priming the active sites, representing a novel mechanism of regulation.

The genome-wide transcriptional regulatory network in Pseudomonas syringae demonstrates the regulatory diversity and functional pathways.

Fitness defects arising from deletion of the gene encoding the bacterial equivalent of actin (mreB) are readily compensated by mutations affecting cell wall synthesis.

Genetically diverse Mycobacterium tuberculosis complex strains induce a gamut of human granulomatous responses in vitro, with a role for IL-1β in aggregate formation.

As Caenorhabditis elegans shifts from reactive to increasingly proactive defensive strategies, nuanced changes in interaction between SEB-3 receptor and NLP-49 peptides regulate the transitions between defensive behaviors.

A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

Salt stress disrupts root-shoot growth coordination through SR3G, a negative regulator of salt tolerance, that affects shoot growth, root suberization, and sodium accumulation, revealing new targets for environmental resilience.

A novel mutant, ^R25CPTH, derived from a hypoparathyroidism patient, can form a dimer that activates PTH1R and enhances bone formation in female mice similar to PTH despite altered molecular properties.

Equations generalizing reward rate maximization are derived, explaining ostensible suboptimal behaviors, revealing time’s cost to comprise apportionment and opportunity costs, and identifying the misestimation in time apportionment as the actual error committed in temporal decision making by animals and humans.