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Remains of the extinct hominin species Homo naledi were interred by members of their own species, the first time that burial has been documented in populations other than modern humans and Neanderthals.

Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.

Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.

A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.

Early immune pressure and co-occurring mutations drive changes in hepatitis C virus fitness and evolution, revealing key dynamics in the establishment of chronic infection.

Gut dysbiosis and specific microbiota composition promoted the absorption of excess palmitic acid in the ileum, driving its accumulation in the serum.

Mesolimbic dopamine ramps emerge only when overall event rates are high, thereby providing a key constraint on theories of dopamine signaling.

Molecular profiling with omics approaches reveals the resemblance between neuroendocrine malignancies and solitary fibrous tumors, rare soft tissue cancers with no effective treatment options.

Reinforcement motor learning of probabilistic tasks shows a protracted developmental trajectory in childhood due to high motor noise and low exploration, though performance deficits can be ameliorated in younger children by reducing task demands in spatial processing and probabilistic reasoning.

Orexin neurons precisely track body movement across behavioral and metabolic states, revealing a neural mechanism that links motor activity to arousal and energy resources.