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Multimodal analysis of human cortical excitatory neurons reveals age-dependent differences.

Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2⁺Ccl7⁺Ccl8⁺C1qa⁺C1qb⁺C1qc⁺ pro-inflammatory macrophages, which can induce the CD8⁺ and Th17 memory T cells generation while inhibiting the gMDSCs production.

Cortex-wide projections onto primary sensory and motor areas display substantial interhemispheric symmetry in their areal input identity and are primarily feedback in nature due to dominant inputs from Layer 6.

Pharmacologically induced hypothermia elicits anticonvulsant, neuroprotective, and anti-inflammatory properties.

DyNoPy is able to deconvolute communities from complicated coevolution analysis.

Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.

DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.

It was revealed that phosphorylation of the DNA repair enzyme PNKP at threonine 118 by CDK is required for DNA replication through the gap filling of Okazaki fragments.

Structure-based approach identifies a K_ATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective K_ATP channel trafficking to the cell surface.

The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.