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Empirical energy landscape allows simulating the structural dynamics of the proteasomal ATPase complex, which yields predictions that are widely consistent with experimental observations and reveals the functional mechanism of the proteasome in substrate degradation.

Spontaneous fluctuations in pupil-indexed arousal shape human cortical dynamics in a frequency-dependent and spatially diverse manner.

Mapping functional relationships between multiple ecosystem services (ES) reveals previously unidentified areas of high ES value, which suggests that the spatial focus of planning for optimal ES provisioning may shift when relationships between several ES are considered.

Four stages of linear and nonlinear computations in hierarchical dynamic brain networks progressively transform the same two visual inputs into the task-specific XOR, AND, and OR behavioral responses.

Mechanotransduction signaling analysis suggests that mechanical tension can sensitize, desensitize, and reverse cell responses to biochemical agonists, as well as provide mechano-adaptive targets for regionally specific drug responses.

Tissue microarrays, a high-throughout approach to quantifying biomarkers used in hundreds of cancer studies every year, are susceptible to batch effects that can alter results but that are readily addressable.

Kidney organoids are a high-fidelity system for investigating basement membrane regulation in development and disease.

When artificial networks modeled on a Drosophila neuron are tasked with discriminating objects on collision course from other visual scenes, their optimized solutions reproduce many functional features of the original loom-selective neuron.

Pioneering activity may be a property of all transcription factors with sufficient affinity for their targets rather than a property of specific classes of transcription factors.

A brain MRI imaging study on brain and manual lateralisation in 50 baboons shows that communicative manual gesturing is related to a Broca's area marker.