Browse our Research Articles

Page 459 of 1,383
    1. Neuroscience

    Cell-type-specific responses to associative learning in the primary motor cortex

    Candice Lee, Emerson F Harkin ... Simon Chen
    Major neuronal subtypes in M1 show differential responses to reward and reward-associated stimuli and undergo cell-type-specific plasticity following associative learning.
    1. Cell Biology
    2. Developmental Biology

    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

    Shu Yang, Xuefeng Wu ... Xiaoyan Zheng
    The NDNF-like factor Nord is a Hedgehog-induced and extracellular-localized dosage-dependent BMP modulator that regulates Drosophila wing patterning and growth.
    1. Neuroscience

    An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

    Mitchell Bishop, Maximilian Weinhold ... Shahriar SheikhBahaei
    The introduced Python tool was used to characterize breathing behaviors of common marmosets in room air and acute hypoxic (10% O2) and hypercapnic (6% CO2) conditions.
    1. Neuroscience

    Influence of sensory modality and control dynamics on human path integration

    Akis Stavropoulos, Kaushik J Lakshminarasimhan ... Dora E Angelaki
    Human path integration accuracy is strongly influenced by the underlying control dynamics, but less so when visual, rather than vestibular, feedback is available.
    1. Ecology
    2. Immunology and Inflammation

    Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

    Charlotte E Davies, Jessica E Thomas ... Christopher J Coates
    Neither the presence nor the intensity of Hematodinium sp. parasitisation drives co-infection occurrence, severity, or diversity in the ecologically ubiquitous shore crab, Carcinus maenas.
    1. Cell Biology
    2. Neuroscience

    A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

    Sergio Velasco-Aviles, Nikiben Patel ... Hugo Cabedo
    Myelin generation during development and nerve regeneration is guaranteed by responsive backup circuits that coordinate class IIa HDACs to repress the expression of negative regulators of myelination and permit Schwann cell differentiation in response to cAMP.
    1. Neuroscience

    Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition

    Mohit Dubey, Maria Pascual-Garcia ... Maarten HP Kole
    Demyelination disrupts fast inhibition of pyramidal neurons, thereby changing neocortical rhythms and causing the emergence of brief epileptic-like discharges.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex

    Jose A Fernandez-Leon, Douglas S Engelke ... Fabricio H Do Monte
    A combination of electrophysiological and optogenetic approaches revealed a causal role for glutamatergic neurons in the prelimbic cortex in regulating individual differences in decision-making strategies during a threat-avoidance vs. reward-approach conflict paradigm in rats.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

    Jacob A Van Winkle, Stefan T Peterson ... Timothy J Nice
    The enteric bacterial microbiota stimulates a highly localized interferon-lambda signal within the intestinal epithelium that protects against murine rotavirus infection.
    1. Medicine

    Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

    Robert N Helsley, Tatsunori Miyata ... Jonathan Mark Brown
    The gut microbe-derived metabolite trimethylamine (TMA) is elevated in patients with alcohol-associated hepatitis and inhibition of the gut microbial enzymes that produce TMA may serve as a tractable therapeutic strategy for the treatment of ethanol-induced liver injury.