Browse our Research Articles

Structures of PKA in complex with wild type and mutant phospholamban show a mechanism underlying familial dilated cardiomyopathy.

A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.

Bioinformatics analyses reveal that the Krüppel-associated box domain zinc finger proteins are associated with DNA methylation of retroelements in human primordial germ cells which highlight potential molecular mechanisms for the regulation of retroelements in human male germ cells.

First-order interneurons in the Drosophila visual system are not ON or OFF pathway-specific inputs, but serve as distinct computational units that distribute different kinds of luminance and contrast information across pathways to achieve stable behavioral responses to visual stimuli.

Intentionally preventing the retrieval of an unwanted memory hinders future attempts to reactivate the memory’s neural representation and causes a reduction in the vividness with which it can be recalled.

Ecdysone-mediated repression of the TMEM16 channel subdued initiates a sensory switch in peripheral nociceptors during Drosophila larval development, increasing thermal nociceptive behavior and reducing responsiveness to ultraviolet light.

Hyperphosphatemia, by itself and in the context of chronic kidney disease, contributes to iron restrictive anemia by directly targeting the liver and elevating proinflammatory cytokines and hepcidin, which contributes to widespread tissue injury, such as skeletal muscle wasting.

Computer simulations explore the experimentally unknown S-protein structures, revealing novel drug binding sites.

Activation of adiponectin receptors in young and aged mice induces changes in muscular metabolism via stimulation of AMPK and PGC-1a and ameliorates age-related muscle loss of function.

When crowded bacterial colonies invade a closed area, flow-induced alignment creates strong radial orientation and leads to the formation of aster defects.