Browse our Research Articles

Page 599 of 1,425
    1. Microbiology and Infectious Disease

    Revisiting the guidelines for ending isolation for COVID-19 patients

    Yong Dam Jeong, Keisuke Ejima ... Marco Ajelli
    Compared with the approach isolating COVID-19 patients for a fixed period, the approach using repeated PCR testing mitigates unnecessarily lengthy isolation of patients while minimizing the risk of further transmission.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat, Matthew W Bowler ... Christopher Swale
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Ecology

    An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites

    Lei Guo, Xin-yu Fan ... Jia Huang
    The structural and pharmacological difference of the invertebrate counterpart of β-adrenergic receptor confers selective toxicity of an insecticide on honeybees and their devastating parasite Varroa mites.
    1. Ecology
    2. Evolutionary Biology

    Living with relatives offsets the harm caused by pathogens in natural populations

    Hanna M Bensch, Emily A O'Connor, Charlie Kinahan Cornwallis
    Experiments show that pathogens spread more easily among relatives causing increased mortality, but such costs are cancelled out by the benefits of living with kin when pathogens are rare.
    1. Neuroscience

    Spike frequency adaptation supports network computations on temporally dispersed information

    Darjan Salaj, Anand Subramoney ... Wolfgang Maass
    Spike frequency adaptation provides spiking neural networks with long short-term memory.
    1. Developmental Biology

    Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

    Shawn A Hallett, Yuki Matsushita ... Noriaki Ono
    Slow-cycling chondrocytes are maintained in a Wnt-inhibitory environment within the resting zone, unraveling a novel mechanism regulating maintenance and differentiation of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells of the postnatal growth plate.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    A Brownian ratchet model for DNA loop extrusion by the cohesin complex

    Torahiko L Higashi, Georgii Pobegalov ... Frank Uhlmann
    A structure-based model of the chromosomal cohesin complex, accompanied by molecular-mechanistic simulations, explains cohesin's key role in topologically entrapping DNA, as well as its ability to alternatively extrude DNA loops.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

    Ryo Miyamoto, Akinori Kanai ... Akihiko Yokoyama
    HOXA9 is a transcriptional maintenance factor for anti-apoptotic genes that accelerate MYC-driven leukemia.
    1. Microbiology and Infectious Disease

    In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

    Kelsey A Haugh, Mark S Ladinsky ... Pradeep D Uchil
    Retroviruses exploit the lectin, Siglec-1/CD169, expressed on sentinel macrophages to promote infection during multiple routes of transmission.
    1. Structural Biology and Molecular Biophysics

    Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

    Fenghui Zhao, Chao Zhang ... Ming-Wei Wang
    The structure provides key insights into hormone recognition and activation of the glucose-dependent insulinotropic polypeptide receptor.