Andreas Gerondopoulos, Philipp Bräuer ... Simon Newstead
KDEL receptor structures with variant HDEL and RDEL signals help decode the cell biological mechanism for the selective retrieval of escaped endoplasmic reticulum luminal proteins.
Kianoush Banaie Boroujeni, Paul Tiesinga, Thilo Womelsdorf
A fast spiking interneuron sub-type in medial and lateral prefrontal cortex fires and gamma-synchronizes prominently during adaptive learning of reward values when outcomes are uncertain and choice options have similar values.
Heather E Machado, Alan O Bergland ... Dmitri A Petrov
Seasonal selection is a general feature of Drosophila melanogaster genetic variation, occurring in North American and European populations and affecting large proportions of the genome.
A new disposition mechanism for glucuronides, where liver serves as recycle organ and intestine serves as metabolism organ, is established to better explain the disposition of phenolics in vivo.
A new mode of inflammasome regulation was discovered through a mouse strain intercross that identified the Pycard locus was associated with IL-1β release, and gene editing showed this was due to an SNP in the Pycard mRNA regulating its turnover.
Loss of heterozygosity (LOH) mediated diversification of the diploid S. cerevisiae hybrid genomes during asexual propagation are vast and exceptionally varied depending on the genetic background.
