Thomas J Etheridge, Desiree Villahermosa ... Johanne M Murray
In vivo single-molecule imaging demonstrates that Smc5/6 chromatin association depends on ATP hydrolysis and dsDNA binding, requires Nse6 and is modulated by Brc1 after DNA damage.
Eugenio Mancera, Isabel Nocedal ... Alexander D Johnson
The transcription networks controlling biofilm formation in Candida species exhibit 'structural' similarities, but show gradual substitutions of transcription regulators and frequent changes in target genes.
In a drug choice setting, rats’ preference is initially driven by deliberative processes but shifts to more automatic selection processes after extended training, in accordance with the sequential choice model.
The synaptic structure in mouse V1 is explained by a synergy of homeostatic plasticity in incoming and outgoing synapses of inhibitory interneurons, establishing a stimulus-specific balance of excitation and inhibition.
Giancarlo Cicconofri, Giovanni Noselli, Antonio DeSimone
The 'spinning lasso' geometry of Euglena's beating flagellum is revealed, and a model based on the antagonistic forces exchanged by axoneme and paraflagellar rod is proposed to explain its emergence.
Markus Terrey, Scott I Adamson ... Susan L Ackerman
Disruption of quality control pathways that function at distinct steps to mitigate errors in translation evoke similar cellular responses and pathologies.
Manuel Giménez-Andrés, Tadej Emeršič ... Alenka Čopič
The amphipathic helix of perilipin 4 relies on the organization of its polar residues to form a remarkably immobile and stable protein layer on the surface of lipid droplets.
Mahmood S Hoseini, Bryan Higashikubo ... Jeanne T Paz
Gamma rhythms and representation of visual information in the primary visual cortex are specifically modulated by somatostatin+ but not parvalbumin+ neurons in reticular thalamic nucleus.
Edoardo Bistaffa, Alba Marín-Moreno ... Fabio Moda
The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.
Large-scale imaging analysis of CA1 reveals that distinct neural networks are involved in trace conditioning versus extinction learning, shedding light on how the hippocampus encodes different types of memory.
