Browse our Research Articles

Page 611 of 1,392
    1. Neuroscience

    Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

    Przemyslaw Jarzebowski, Clara S Tang ... Y Audrey Hay
    Elevated cholinergic activity disrupts offline hippocampal state and impairs memory formation highlighting the need for a precise timing of cholinergic activity in learning and memory.
    1. Physics of Living Systems

    Robust, coherent, and synchronized circadian clock-controlled oscillations along Anabaena filaments

    Rinat Arbel-Goren, Valentina Buonfiglio ... Joel Stavans
    Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby, Candice L Clarke ... James E Peters
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
    1. Evolutionary Biology

    The essential role of Dnmt1 in gametogenesis in the large milkweed bug Oncopeltus fasciatus

    Joshua T Washington, Katelyn R Cavender ... Patricia J Moore
    The maintenance DNA methyltransferase DNMT1 is required for the transition of spermatogonia to spermatocytes both during larval testis development and adult sperm replenishment in the insect Oncopeltus fasciatus.
    1. Neuroscience

    Optimal policy for attention-modulated decisions explains human fixation behavior

    Anthony I Jang, Ravi Sharma, Jan Drugowitsch
    A normative decision-making model that incorporates an information-limiting attention bottleneck is able to qualitatively replicate human behavior and make novel predictions that are verified in data.
    1. Physics of Living Systems

    Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

    Monika E Dolega, Sylvain Monnier ... Giovanni Cappello
    Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.
    1. Neuroscience

    Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates

    Amanda Klein, Hans Jürgen Solinski ... Matthias Ringkamp
    MRGPRD and MRGRPX1 are co-expressed in primate DRG neurons, but β-alanine and BAM8-22, preferentially activate CMH-subclasses, and co-activating different cutaneous nociceptors by pruritogens does not change itch sensation to pain.
    1. Cell Biology

    Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain

    Nadia Formicola, Marjorie Heim ... Florence Besse
    Tyramine-dependent signaling triggers decondensation of neuronal RNP components and rapid translation activation of target mRNAs.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microbial genetic and transcriptional contributions to oxalate degradation by the gut microbiota in health and disease

    Menghan Liu, Joseph C Devlin ... Lama Nazzal
    A novel multi-omics framework revealed the taxonomic contribution to microbiota oxalate, demontrated O. formigenes as the dominating taxon transcriptionally, and identified specific IBD cohort at risk for oxalte toxicity.
    1. Physics of Living Systems

    Ligand sensing enhances bacterial flagellar motor output via stator recruitment

    Farha Naaz, Megha Agrawal ... KV Venkatesh
    Sensing of ligands by chemoreceptors of Escherichia coli not only causes changes in the rotational bias of the flagellar motors but also increases motor speed via temporary recruitment of stators.