Browse our Research Articles

The effect of genetic variation on gene expression can be specific down to the level of individual cells.

A genome-wide catalog of the regulatory effects of variants that separate modern humans from archaic humans.

Drosophila macrophages are a heterogeneous population of cells containing subpopulations with enhanced responses to injury that display considerable variation in their abundance across development.

The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.

Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.

A combination of equilibrium and nonequilibrium molecular dynamics simulations is an effective tool to study allosteric communications in ultrafast enzymes that show little or no conformational changes.

Declined coding of sensory information in the brain reflects human vigilance decrements and allows prediction of behavioural errors.

Emerging approaches in larval zebrafish to identify safe opioid therapies without the side-effect of respiratory depression.

Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.

Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.