Browse our Research Articles

Page 612 of 1,446
    1. Cell Biology
    2. Immunology and Inflammation

    Galectin-9 regulates the threshold of B cell activation and autoimmunity

    Logan K Smith, Kareem Fawaz, Bebhinn Treanor
    Galectin-9-deficient mice develop spontaneous autoimmunity, driven by a decreased threshold of B cell activation and enhanced auto-antigen delivery to the spleen by increased B1a-derived autoantibodies.
    1. Cancer Biology
    2. Medicine

    Association of human breast cancer CD44-/CD24- cells with delayed distant metastasis

    Xinbo Qiao, Yixiao Zhang ... Caigang Liu
    CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).
    1. Neuroscience

    Differential conditioning produces merged long-term memory in Drosophila

    Bohan Zhao, Jiameng Sun ... Yi Zhong
    Although flies cannot discriminate shock-paired and -unpaired odor 24 hr after single-trial aversive conditioning, they choose to avoid both of them, which is derived from a merged long-term memory.
    1. Genetics and Genomics

    HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

    Jessica SY Ho, Federico Di Tullio ... Ernesto Guccione
    HNRNPM regulates exon inclusion and circularization events on transcripts of key homeostatic genes promoting cancer growth.
    1. Structural Biology and Molecular Biophysics

    Discovery and characterization of Hv1-type proton channels in reef-building corals

    Gisela Rangel-Yescas, Cecilia Cervantes ... Leon D Islas
    Proton channels are present in reef-building corals and constitute important molecular players that should help understand calcification and the response of these organisms to ocean acidification.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

    Irene Unterman, Idit Bloch ... Yuval Tabach
    A novel comparative genomics framework identifies MECP2 network proteins targeted by existing drugs, with three drugs validated in an in vitro Rett syndrome model.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa, Cody J Hall ... Matthew A Perugini
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Topography and motion of acid-sensing ion channel intracellular domains

    Tyler Couch, Kyle D Berger ... David M Maclean
    The cytosolic elements of the acid-sensing ion channel move toward the plasma membrane when the channel is exposed to acidic conditions.
    1. Neuroscience

    The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo

    Monique S Mendes, Linh Le ... Ania K Majewska
    Adult microglia are born by the division of single surviving microglia that rapidly acquire mature morphologies and functions in order to perform their physiological roles in the brain.
    1. Neuroscience

    Transcriptomic encoding of sensorimotor transformation in the midbrain

    Zhiyong Xie, Mengdi Wang ... Xiaoqun Wang
    Single-cell RNA-sequencing and neural circuitry analyses reveal that sensorimotor transformation of different behaviors which are performed by separate circuit modules in the superior colliculus are molecularly defined by distinct transcriptomic codes of specific neuron subtypes.