Browse our Research Articles

Page 612 of 1,424
    1. Medicine
    2. Neuroscience

    Stimulus-induced gamma rhythms are weaker in human elderly with mild cognitive impairment and Alzheimer’s disease

    Dinavahi VPS Murty, Keerthana Manikandan ... Supratim Ray
    Visual narrow-band gamma rhythms are reduced in mild cognitive impairment and Alzheimer’s disease, confirming previous rodent research and forming crucial first steps for development of EEG-based biomarkers for humans.
    1. Cell Biology
    2. Developmental Biology

    Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

    Helen Schmidt, Andrea Putnam ... Geraldine Seydoux
    P granule assembly depends in part on protein-protein interactions that drive condensation independent of RNA.
    1. Cancer Biology

    Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

    Xin Zhou, Jennifer W Li ... Lizi Wu
    Targeting aberrant CRTC-CREB activation blocks the growth of LKB1-inactivated lung cancer.
    1. Neuroscience

    Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity

    Tom P Franken, Brian J Bondy ... Philip X Joris
    The location of impact sounds, common stimuli whose detection is crucial for survival, is encoded by a precise interaction between excitation and inhibition rather than coincidence detection of excitatory events.
    1. Medicine

    Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

    Cheng-Chia Tang, Christian D Castro Andrade ... Marc N Wein
    Simultaneous inhibition of two distinct kinase targets stimulates bone formation without concurrently increasing bone resorption, therefore representing a promising new treatment strategy for osteoporosis.
    1. Microbiology and Infectious Disease

    Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

    Sem H Jacobs, Eva Dóró ... Maria Forlenza
    Transparent zebrafish, reveal the occurrence of foamy macrophages during an extracellular trypanosome infection and their association with an exacerbated inflammatory response.
    1. Biochemistry and Chemical Biology

    Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life

    Raphaël Méheust, Shuo Huang ... Samuel H Light
    Bioinformatic and biochemical studies provide evidence that covalently bound flavins are common and participate in wide-ranging extracytosolic redox activities throughout bacterial life.
    1. Cancer Biology

    Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

    Shawn McGuirk, Yannick Audet-Delage ... Julie St-Pierre
    Breast cancer resistant to either doxorubicin or epirubicin relies on distinct primary metabolic processes, which can be targeted to reduce cancer progression.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    High-speed, three-dimensional imaging reveals chemotactic behaviour specific to human-infective Leishmania parasites

    Rachel C Findlay, Mohamed Osman ... Laurence G Wilson
    High-speed holographic microscopy shows that Leishmania parasites modify their swimming behaviour to target human macrophages.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

    Amy R Strom, Ronald J Biggs ... Andrew D Stephens
    Micromanipulation experiments demonstrate that HP1α strengthens interphase and mitotic chromosome mechanics and maintains nuclear shape by chromatin crosslinking, separate from histone methylation.