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A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.

The orientation of the TCR extracellular domain is highly variable and coupled to characteristic structural changes throughout the TCR - CD3 complex.

PX-BAR Mvp1 and dynamin-like GTPase Vps1 drive retromer-independent endosomal recycling.

Serial-section electron microscopy uncovers the intricate neural network of the bumblebee central complex, revealing highly conserved projection patterns as well as novel circuit elements potentially unique to bees.

An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.

By recording simultaneous spike trains from fear-responsive basal amygdala (BA) and place-responsive dorsal hippocampus (dHPC) neurons in rats foraging for food in a risky predatory situation, a novel BA-dHPC circuit coding mechanism for interfacing danger and place information was revealed.

The BNT162b2 mRNA COVID-19 vaccine is highly effective at generating immune responses in people over the age of 80 years and provides good cross neutralization of the P.1 gamma variant of concern.

A new tracking method revealed the social-like interactions in the Mexican blind cavefish, which was thought to be evolutionarily lost, and also demonstrated its mammal-like antagonistic association between the social-like interaction and repetitive behavior.

Maintenance of peripheral myonuclei patterning in skeletal myofibers is dependent on the regulation of microtubules dynamic and nuclei motion and is essential for proper neuromuscular junction integrity and mitochondria homeostasis.

Filopodia driven by class X myosin promote the fusion of mammalian myoblasts in the development of skeletal muscle and are important for the regeneration of skeletal muscle following muscle injury.