Chitinase 3-like-1 promotes Kupffer cells to recruit platelets, thereby contributing to liver injury, and serves as a therapeutic target in acetaminophen-induced liver injury.
Florian A Dehmelt, Rebecca Meier ... Aristides B Arrenberg
Systematic stimulation across the entire visual field reveals that zebrafish optokinetic behavior is most strongly driven by lateral stimulus locations, as a result of both retinal and extra-retinal effects.
Ellen KW Brennan, Izabela Jedrasiak-Cape ... Omar J Ahmed
Parallel input streams to layer 1 identify a computationally distinct principal neuronal subtype ideally positioned to support spatial orientation computations in the granular retrosplenial cortex.
M Ines Pascoal Ramos, Linjie Tian ... Linde Meyaard
NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction, might be a powerful new strategy for cancer immunotherapy for collagen-rich immune-excluded tumors.
T-cell receptor signaling actively regulates gating of the nuclear pore complex (NPC) in T cells by inducing translocation of protein kinase C-θ to the NPC to promote the sumoylation of RanGAP1.
Tim-3 promotes the ubiquitination and degradation of NF90, a novel virus sensor, and negatively regulates the NF90-SG pathway-mediated antiviral innate immunity.
Individual participant data meta-analysis reveals the estimated lifespan trajectory of cortical GABA, characterized by an early rapid increase, followed by a period of stability during early adulthood, and a gradual decrease.
