Browse our Research Articles

Page 653 of 1,403
    1. Evolutionary Biology

    Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

    Thomas Sakoparnig, Chris Field, Erik van Nimwegen
    For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    In-host population dynamics of Mycobacterium tuberculosis complex during active disease

    Roger Vargas, Luca Freschi ... Maha Reda Farhat
    Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

    Laura E Doepker, Sonja Danon ... Julie M Overbaugh
    HIV-specific antibodies that mediate antibody-dependent cellular cytotoxicity vary in their paths to achieve function but commonly rely on mutations in multiple regions, including framework regions, to reach full potency.
    1. Genetics and Genomics

    GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

    Nasa Sinnott-Armstrong, Sahin Naqvi ... Jonathan K Pritchard
    Across urate, IGF-1, and testosterone, thousands of dispersed variants contribute to heritability, while previously characterized core pathways are highly enriched for associations and reveal feedback mechanisms governing serum biomarker levels.
    1. Neuroscience

    Temporo-parietal cortex involved in modeling one’s own and others’ attention

    Arvid Guterstam, Branden J Bio ... Michael Graziano
    Functional brain scans of human participants show that the brain encodes other people's attention in enough richness to distinguish whether that attention was directed exogenously (stimulus-driven) or endogenously (internally driven).
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

    Charlotte P Choi, Rebecca J Tay ... John K Kim
    snpc-1.3 specifies male piRNA transcription and is regulated by the sex determination pathway.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

    Christoph Heier, Oskar Knittelfelder ... Ronald P Kühnlein
    An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

    Patrick T Dolan, Shuhei Taguwa ... Judith Frydman
    Distinct selective landscapes in mosquito and human cells shape dengue virus genetic diversity and highlight mechanisms of host adaptation in arboviruses.
    1. Neuroscience

    A new model of decision processing in instrumental learning tasks

    Steven Miletić, Russell J Boag ... Andrew Heathcote
    A new model is presented to simultaneously study the latent cognitive processes underlying decision making and instrumental learning.
    1. Immunology and Inflammation

    The clonal structure and dynamics of the human T cell response to an organic chemical hapten

    Tahel Ronel, Matthew Harries ... Benny Chain
    Chronic exposure to a potent chemical contact sensitizer drives a self-limiting expansion of a polyclonal population of T cells recognizing a small number of dominant antigens.