Hippocampal and prefrontal neuronal populations form slow behavioral-timescale (~seconds) and fast cognitive-timescale (~100 ms) sequential activity patterns as theta and replay sequences, which play distinct yet cooperative roles in memory-guided decision-making.
Viplendra PS Shakya, William A Barbeau ... Adam L Hughes
During times of mitochondrial impairment, non-imported mitochondrial precursor proteins are targeted to the nucleus for proteasome-dependent degradation.
J Roman Arguello, Liliane Abuin ... Richard Benton
Targeted expression of molecular probes for gene expression and chromatin accessibility in subpopulations of neurons in the Drosophila olfactory system identifies genes required for their development and function.
Sina C Rosenkranz, Artem A Shaposhnykov ... Manuel A Friese
Inducing neuronal mitochondrial activity during central nervous system inflammation counteracts inflammation-induced neuronal electron transport chain deficiency and calcium toxicity, thereby protecting against neuronal loss in a multiple sclerosis mouse model.
Swati Gaikwad, Fardin Ghobakhlou ... Alan G Hinnebusch
A mutant impaired for ribosome recycling exhibits translational reprogramming wherein strong mRNAs outcompete weak mRNAs, also observed when preinitiation complexes are diminished by eIF2α phosphorylation or 40S ribosomal subunit depletion.
Gregory G Grecco, Briana E Mork ... Brady K Atwood
A novel, translational mouse model of prenatal methadone exposure was developed and a longitudinal assessment of offspring revealed impairments in physical, behavioral, and neuronal development.
Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
Nina Kirstein, Alexander Buschle ... Aloys Schepers
Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.
Dominik Schumacher, Andrea Harms ... Lotte Søgaard-Andersen
In the PomX/Y/Z cell division regulatory system, PomX is a PomZ ATPase activating protein, a scaffold for PomX/Y/Z complex formation, and important for fission of the PomX/Y/Z complex during division.
