Browse our Research Articles

Page 727 of 1,393
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati, Marcela de Souza Santos ... Kim Orth
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Chromosomes and Gene Expression

    Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

    Juan Lafuente-Barquero, Maria Luisa García-Rubio ... Andrés Aguilera
    RNA does not form DNA:RNA hybrids in trans that compromise genome integrity.
    1. Developmental Biology

    Intrinsic control of muscle attachment sites matching

    Alexandre Carayon, Laetitia Bataillé ... Jean-Louis Frendo
    Making a link between deletion of transcription cis-regulatory elements by CrispR/Cas9, obtention of mutants with single muscle morphology defects and their impact on locomotion.
    1. Ecology
    2. Evolutionary Biology

    Temperature stress induces mites to help their carrion beetle hosts by eliminating rival blowflies

    Syuan-Jyun Sun, Rebecca M Kilner
    Temperature, the presence of an enemy species and the density of the mutualistic partner species interact to determine the expression of a protective mutualism.
    1. Chromosomes and Gene Expression

    Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3

    Lianna Schwartz-Orbach, Chenzhen Zhang ... Sam G Gu
    H3K23me3 is a RNAi-mediated transgenerationally heritable heterochromatin mark in Caenorhabditis elegans.
    1. Structural Biology and Molecular Biophysics

    Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

    Katherine E Huffer, Antoniya A Aleksandrova ... Kenton J Swartz
    Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.
    1. Physics of Living Systems

    A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute

    Jonathan Desponds, Massimo Vergassola, Aleksandra M Walczak
    Maternal positional information in the fly embryo can be read rapidly in spite of the gene-expression bottleneck and general examples of regulatory architectures that combine speed and accuracy are provided.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

    Jing Xue, Tian Xie ... Xiao-chen Bai
    Cryo-EM analysis of human ZnT8 reveals a large conformational change of TMD during the transport cycle.
    1. Cancer Biology
    2. Immunology and Inflammation

    Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

    Biancamaria Ricci, Eric Tycksen ... Roberta Faccio
    Osterix, a transcription factor regulating osteoblast differentiation and bone formation, is expressed in subsets of CAFs with osteogenic features and marks tumor infiltrating immune populations enriched in immune suppressive markers.
    1. Neuroscience

    Disynaptic cerebrocerebellar pathways originating from multiple functionally distinct cortical areas

    Julia U Henschke, Janelle MP Pakan
    Anatomical projections from sensory, motor, and association cortex to the cerebellum are precisely mapped, including cortical-precerebellar connections and terminal organization, providing insight into how the cerebellum may utilize cortical information.