Matthew WK Wong, Anbupalam Thalamuthu ... Perminder S Sachdev
A minor subset of plasma lipids are heritable, and this is associated with gene expression of transcripts related to roles beyond lipid metabolism, including immune function and cell signalling.
The major cytosolic yeast peroxiredoxin Tsa1 controls aging and H2O2-resistance by inhibiting protein kinase A through a conserved cysteine in the catalytic subunit activation loop and not by scavenging H2O2.
Hyperglycaemia increases influenza severity by damaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema during Influenza A virus infection.
Yuliya Voskobiynyk, Jonathan R Roth ... Erik D Roberson
BIN1 forms a complex with Tau and voltage-gated calcium channels in neurons, and higher BIN1 levels promote neuronal activity, calcium influx, and bursting that is blocked by reducing Tau.
Gabriele Valentini, Nobuaki Mizumoto ... Sara I Walker
Information theory reveals that apparently similar signaling behaviors in ants and termites are instead governed by distinct communication protocols explaining their underlying different functions.
A plant virus, Tomato yellow leaf curl virus, manipulates the host preference of the vector insect whitefly to promote its transmission by inducing caspase-dependent apoptotic neurodegeneration in vector's brain.
The prefrontal cortex encodes both stable and dynamic representations of expected value, providing mechanisms to support robust as well as flexible access to value information during temporal delays.
Flavia Camponovo, Joseph J Campo ... Melissa A Penny
Malaria pre-exposed volunteers exhibit large breadth of humoral immune responses, with strong variation between individuals, which might compromise vaccine-induced humoral immune response due to natural imprinting.
