Browse our Research Articles

Page 741 of 1,392
    1. Immunology and Inflammation

    Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR+NKG2A- NK cells

    Sabrina Bianca Bennstein, Sandra Weinhold ... Markus Uhrberg
    Neonatal ILC1-like cells are functionally immature but have the unique potential to generate NK cells characterized by downregulation of NKG2A and a highly diverse KIR receptor repertoire.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis

    Linda Grigoraki, Xavier Grau-Bové ... Hilary Ranson
    Delineation of the cuticular hydrocarbon biosynthetic pathway in malaria vectors is a key step in understanding how mosquitoes adapt to anthropogenic change and vector control interventions.
    1. Immunology and Inflammation

    CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation

    Joan Manils, Louise V Webb ... Steven C Ley
    Expression of a psoriasis-associated CARD14E138A mutant in keratinocytes induces TNF-dependent localised skin and systemic inflammation independently of the adaptive immune system.
    1. Cell Biology
    2. Genetics and Genomics

    A trans-eQTL network regulates osteoclast multinucleation and bone mass

    Marie Pereira, Jeong-Hun Ko ... Jacques Behmoaras
    MMnet is a conserved, trans-regulated gene network that controls skeletal homeostasis through osteoclast multinucleation and bone resorptive function.
    1. Microbiology and Infectious Disease

    Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

    Dennis Klug, Sarah Goellner ... Friedrich Frischknecht
    Exchange of the I domain in the Plasmodium surface protein TRAP against evolutionary distant I domains rescues infectivity of sporozoites.
    1. Biochemistry and Chemical Biology

    Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

    Iti Kapoor, Philip Olivares, Satish K Nair
    Biochemical and structural biological analyses show how bacteria can recognize hormones that control the production of important secondary metabolites such as antiparasitics and antibiotics.
    1. Neuroscience

    Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models

    Menoua Keshishian, Hassan Akbari ... Nima Mesgarani
    A comprehensive, data-driven and interpretable nonlinear computational modeling framework based on deep neural networks uncovers different nonlinear transformations of speech signal in the human auditory cortex.
    1. Developmental Biology

    Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila

    Satish Kumar Tiwari, Ashish Ganeshlalji Toshniwal ... Lolitika Mandal
    Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in Drosophila..
    1. Neuroscience

    A size principle for recruitment of Drosophila leg motor neurons

    Anthony W Azevedo, Evyn S Dickinson ... John C Tuthill
    Motor neurons controlling the leg of the fruit fly exhibit a gradient of physiological and functional properties that correlate with the order in which they fire during behavior.
    1. Neuroscience

    Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

    Nathan Cermak, Stephanie K Yu ... Steven W Flavell
    Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.