Browse our Research Articles

Page 770 of 1,395
    1. Cell Biology
    2. Immunology and Inflammation

    Rapamycin rejuvenates oral health in aging mice

    Jonathan Y An, Kristopher A Kerns ... Matt Kaeberlein
    Short-term treatment with rapamycin reverses periodontal bone loss, attenuates inflammation, and remodels the oral microbiome toward a more youthful state.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

    Julia Bittmann, Rokas Grigaitis ... Boris Pfander
    The development of an advanced cell cycle tag toolbox will enable a wide variety of cell cycle studies and shows post-replicative function of nucleases resolving replication/recombination structures.
    1. Cell Biology

    Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

    Leilei Zhong, Lutian Yao ... Ling Qin
    A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
    1. Cell Biology
    2. Immunology and Inflammation

    Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

    Maria-Bernadette Madel, Lidia Ibáñez ... Claudine Blin-Wakkach
    Osteoclasts emerging in inflammation are heterogeneous and encompass a strongly inflammatory subset with a high resorbing activity and an immune suppressive subset that are able to control each other.
    1. Cancer Biology
    2. Genetics and Genomics

    Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

    Timour Baslan, Jude Kendall ... James Hicks
    Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.
    1. Structural Biology and Molecular Biophysics

    Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

    Sathish Ramakrishnan, Manindra Bera ... Shyam S Krishnakumar
    Cooperative action of synaptotagmin and complexin is needed to arrest all SNARE complexes on a vesicle, and the reversal of the synaptotagmin clamp is sufficient to achieve fast, Ca2+-synchronized fusion.
    1. Neuroscience

    Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo

    Jin Bao, Michael Graupner ... Isabel Llano
    During parallel fibre activity in vivo, postsynaptic mGluR1 receptors in molecular layer interneurons of the cerebellar cortex are engaged in a frequency-dependent manner and in concert with inotropic glutamate receptors.
    1. Neuroscience

    Pre-stimulus phase and amplitude regulation of phase-locked responses are maximized in the critical state

    Arthur-Ervin Avramiea, Richard Hardstone ... Klaus Linkenkaer-Hansen
    Critical networks show maximum pre-stimulus phase and amplitude regulation of stimulus-evoked responses.
    1. Neuroscience

    Efficient recognition of facial expressions does not require motor simulation

    Gilles Vannuscorps, Michael Andres, Alfonso Caramazza
    It is possible to account for efficient facial expression recognition without having to invoke a mechanism of motor simulation, even in very sensitive and challenging tasks.
    1. Neuroscience

    Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington’s nucleus CRH neurons

    Hiroki Ito, Anna C Sales ... Anthony E Pickering
    Ponto-spinal CRH neurons in Barrington’s nucleus are a core component of an inferential circuit that regulates autonomous micturition and generates voids when the bladder is full.