Live imaging and genetic analyses revealed that notochord vacuoles play a critical role in spine morphogenesis by absorbing vertebral bone growth, thus implicating notochord mechanics in congenital scoliosis.
Jennifer A Taylor, Benjamin P Bratton ... Nina R Salama
The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
Michael L Wallace, Kee Wui Huang ... Bernardo L Sabatini
Single-cell transcriptional profiling reveals distinct neuronal subtypes of the lateral habenula differentially target downstream neuronal subtypes in the ventral tegmental area and dorsal raphe nucleus.
Jonathan M Philpott, Rajesh Narasimamurthy ... Carrie L Partch
A conformational switch in the Casein Kinase 1 activation loop controls substrate preference to regulate the abundance of the clock protein PERIOD2 and circadian timekeeping.
Terese Sara Høj Jørgensen, Gunhild Tidemann Okholm ... Merere Osler
Taller body height in young adulthood, as marker of early-life environment, is associated with lower risk of dementia diagnosis independently of cognitive reserve and family factors shared among brothers.
Non-synaptic electrical events recorded simultaneously from pairs of neurons in the inferior olive nucleus enables accurate estimation of the size and of the clustered organization of the electrically coupled network.
Biological ages have the potential to provide aging-related information beyond chronological age and can be predictive of mortality independently of both chronological age and different types of biological ages.
