Kanokwan Champasa, Caitlin Blank ... Stephen P Bell
Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.
Travis J Morgenstern, Jinseo Park ... Henry M Colecraft
A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.
Rebecca A Callahan, Richard Roberts ... Martha W Bagnall
Two anatomically and genetically distinct subtypes of spinal V2b neurons provide inhibition onto motor circuits and serve as a brake on locomotor speed.
USP49 can increase A3G protein expression and enhance its anti-HIV-1 activity, which is also correlated with hypermutations and affects the HIV-1 latent reservoir.
Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
Rosa María Marión, Juan J Montero ... Maria A Blasco
Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
Blood flow-driven shear forces guide the sequential signaling of two antagonistic paired receptors, a critical bi-facet step that first supports leukocyte docking, then initiates transmigration through endothelium.
