Browse our Research Articles

Page 961 of 1,383
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

    Leon Y Chan, Christopher F Mugler ... Karsten Weis
    Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
    1. Immunology and Inflammation

    Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

    Gaojian Lian, JN Rashida Gnanaprakasam ... Ruoning Wang
    Metabolic reprogramming in suppressing oxidative stress during TH17 cell differentiation.
    1. Neuroscience

    Poor coherence in older people's speech is explained by impaired semantic and executive processes

    Paul Hoffman, Ekaterina Loginova, Asatta Russell
    Remaining focused on the topic at hand when speaking depends on effective selection of task-relevant semantic knowledge, and declines in this ability account for increases in off-topic speech in older people.
    1. Neuroscience

    Building a functional connectome of the Drosophila central complex

    Romain Franconville, Celia Beron, Vivek Jayaraman
    The central complex, a highly conserved insect brain region important for navigation, is characterized by a high degree of recurrence and a sparseness of output pathways.
    1. Neuroscience

    Adaptation after vastus lateralis denervation in rats demonstrates neural regulation of joint stresses and strains

    Cristiano Alessandro, Benjamin A Rellinger ... Matthew C Tresch
    The adaptation strategy used by the nervous system following muscle paralysis restores task performance while minimizing the stresses and strains within a joint.
    1. Neuroscience

    Causal contribution and dynamical encoding in the striatum during evidence accumulation

    Michael M Yartsev, Timothy D Hanks ... Carlos D Brody
    Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.
    1. Medicine
    2. Neuroscience

    Prognostication of chronic disorders of consciousness using brain functional networks and clinical characteristics

    Ming Song, Yi Yang ... Tianzi Jiang
    Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.
    1. Cancer Biology
    2. Medicine

    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

    Haley Hieronymus, Rajmohan Murali ... Charles L Sawyers
    The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
    1. Cell Biology

    Cyclin-dependent kinase control of motile ciliogenesis

    Eszter K Vladar, Miranda B Stratton ... Jeffrey D Axelrod
    Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
    1. Developmental Biology

    An intrinsic cell cycle timer terminates limb bud outgrowth

    Joseph Pickering, Constance A Rich ... Matthew Towers
    Size control in limbs is an intrinsically determined process.