Browse our Research Articles

Page 962 of 1,383
    1. Developmental Biology
    2. Cell Biology

    Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

    Ariel M Pani, Bob Goldstein
    Free, extracellular dispersal of Wnt proteins generates a long-range gradient during animal development and is required for signaling.
    1. Microbiology and Infectious Disease

    Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins

    Aaron G Wexler, Whitman B Schofield ... Andrew L Goodman
    The human gut bacterial lipoprotein BtuG binds vitamin B12 with femtomolar affinity, can remove vitamin B12 from human intrinsic factor, and is required for commensal fitness in the gut.
    1. Chromosomes and Gene Expression

    Six domesticated PiggyBac transposases together carry out programmed DNA elimination in Paramecium

    Julien Bischerour, Simran Bhullar ... Mireille Bétermier
    The machinery that carries out programmed DNA rearrangements is composed of domesticated transposases. One is catalytically active, five play architectural function essential for the accuracy of the process.
    1. Ecology

    Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly

    Inés Martínez, Maria X Maldonado-Gomez ... Jens Walter
    Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.
    1. Stem Cells and Regenerative Medicine

    Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

    John B Lees-Shepard, Sarah-Anne E Nicholas ... David J Goldhamer
    Daily palovarotene treatment reduces pathogenic expansion of fibro/adipogenic progenitors but results in long bone growth plate loss and overgrowths of synovial cartilage in juvenile mice.
    1. Plant Biology

    Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry

    Firas Bou Daher, Yuanjie Chen ... Siobhan A Braybrook
    Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.
    1. Cell Biology

    Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

    William A Kronert, Kaylyn M Bell ... Sanford I Bernstein
    Integrative analysis of a Drosophila model of hypertrophic cardiomyopathy demonstrates that prolonged binding of the myosin cross-bridge to actin is a root cause of the disorder.
    1. Cell Biology

    PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

    Andrew Michael Sydor, Etienne Coyaud ... Vito Mennella
    The previously uncharacterized protein PPP1R35 is a novel centriolar luminal protein critical for centriole elongation by acting in a complex with microcephaly protein RTTN.
    1. Evolutionary Biology
    2. Plant Biology

    Negative regulation of conserved RSL class I bHLH transcription factors evolved independently among land plants

    Suvi Honkanen, Anna Thamm ... Liam Dolan
    An ancient and conserved genetic mechanism for cell differentiation is under distinct negative regulation in different lineages of land plants.
    1. Neuroscience

    Conditioning sharpens the spatial representation of rewarded stimuli in mouse primary visual cortex

    Pieter M Goltstein, Guido T Meijer, Cyriel MA Pennartz
    Stimulus-reward learning sharpens the local representation of the visual space while leaving the overall retinotopic map intact.