A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.
Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
For the first time, high-frequency terahertz stimulation is shown to effectively alleviate chronic pain symptoms in mice by regulating neuronal activity in the cortex.
Long-latency reflexes flexibly encode future goals during sequential reaching movements, reflecting the parallel and task-dependent processing of a sequence of goals in circuits that mediate fast feedback control.
Whole-night fMRI-based sleep classification uncovers distinct substates within N2 and REM sleep stages, along with a transition structure between them.
Artem N Bonchuk, Konstantin I Balagurov ... Pavel G Georgiev
The cryo-EM structure of the CG6765 BTB domain and solution scattering experiments revealed a unique three-dimer hexameric assembly for the arthropod Tramtrack group BTB domains.
The autobiographical memory deficits seen in aphantasia are reflected by altered activation and connectivity patterns of the hippocampus and occipital cortex, corroborating the strong link between memory and mental imagery.
GDNF receptor-expressing mesenchymal progenitor subpopulation within skeletal muscle responds to peripheral nerve injury by sensing GDNF and secreting BDNF, thereby directly promoting nerve regeneration through facilitating remyelination by Schwann cells.
Exchange of components between biomolecular condensates and the surrounding dilute phase can be limited by dense-phase mixing, dilute-phase influx, or by the slow incorporation of molecules through the condensate interface.
