The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
Antibody-mediated neutralisation of Gremlin-1 was ineffective in treating fibrosis in metabolic dysfunction-associated steatohepatitits, likely due to low hepatic expression in a subset of myofibroblasts and redundant Gremlin-1 signalling.
Ann-Kathrin Rößling, Kai Dünser ... Jürgen Kleine-Vehn
The methylation status of pectin acts as a critical signalling scaffold for RALF peptides, linking extracellular matrix dynamics to peptide hormone-mediated regulation of plant root growth.
Evgenia Leikina, Jarred M Whitlock ... Leonid Chernomordik
Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.
New morphological information on the Cambrian artiopodan Acanthomeridion, including CT data, demonstrate that dorsal ecdysial sutures likely evolved multiple times within this group.
Sensations arising from internal organs like the heart can affect how the brain decides between two mutually incompatible perceptions of the same visual stimulus.
Information exchange between the sensory cortex (hMT+) and cognition core (BA46), coupled with hMT+ GABA levels, predicts performance in 3D visuo-spatial ability.
