Browse our Research Articles

Transcriptional regulatory network models can aid in identifying candidate genes associated with the target phenotype in bacterial genome-wide association studies.

Multiple walker supervised molecular dynamics simulations deliver insights on glucagon-like peptide 1 receptor activation, G_s protein binding, and guanosine diphosphate release from the G_sα subunit using an adaptive sampling approach.

In recurrently connected cortical networks with different inhibitory neuron subtypes, circuit modulations can increase neuronal gain without compromising network stability.

Phosphoproteomics identifies diverse CaM kinase substrates, while genetic dissection reveals an unexpected antagonistic interaction with calcineurin signaling that operates in distinct neurons to regulate thermo-nociception in Caenorhabditis elegans.

Bulding a cardiolipin binding site into a computationally designed transmembrane protein uncovers how proteins can recognize specific lipids and use them to regulate their function.

Mammalian cells are capable of loading MCM2-7 to support DNA replication in the absence of ORC to permit extensive DNA replication in vivo.

Muscle contraction forces shape tenocyte gene expression, with sequencing and spatial analyses revealing unique force-dependent gene regulation patterns, suggesting tenocytes fine-tune tendon matrix in response to varied mechanical cues.

Integrated multi-omics analyses reveal the metabolism-independent role of nuclear IDH1 in chromatin remodeling during human erythropoiesis.

During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.

Place cells that show repeating place fields in geometrically similar locations of an environment modulate their firing rates differently in each field based on movement direction.