Browse our Research Articles

Page 985 of 1,402
    1. Neuroscience

    Motoneuron Wnts regulate neuromuscular junction development

    Chengyong Shen, Lei Li ... Lin Mei
    A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.
    1. Plant Biology

    DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

    Amr Nassrallah, Martin Rougée ... Fredy Barneche
    Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
    1. Cancer Biology

    tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

    Myron S Ignatius, Madeline N Hayes ... David M Langenau
    Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal rhabdomyosarcoma (ERMS), likely accounting for increased aggression in TP53-inactivated human ERMS.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway

    Zheng Wang, Catherine Wu ... Tony Hunter
    The SUMO-Ub-Cdc48 pathway is a novel regulatory mechanism of Pol III and a potential therapeutic target for Pol III-related human diseases.
    1. Neuroscience

    Integrated externally and internally generated task predictions jointly guide cognitive control in prefrontal cortex

    Jiefeng Jiang, Anthony D Wagner, Tobias Egner
    The dorsolateral prefrontal cortex integrates concurrent externally and internally generated predictions of task demand to guide information processing, while the medial prefrontal cortex corrects its prediction error based on actual task demand.
    1. Plant Biology

    Arabidopsis formin 2 regulates cell-to-cell trafficking by capping and stabilizing actin filaments at plasmodesmata

    Min Diao, Sulin Ren ... Shanjin Huang
    Cytological and biochemical analyses reveal Arabidopsis formin 2 is involved in regulating PD permeability by anchoring actin filaments to PD and stabilizing them through actin filament barbed end capping activity.
    1. Developmental Biology

    E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

    Gwenvael Le Dréau, René Escalona ... Elisa Marti
    Rather than acting as passive and neutral co-factors for proneural proteins, E proteins play an active role in modulating the way the distinct proneural proteins instruct neurogenesis.
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour, Mohammadkarim Saeedghalati ... Daniel Hoffmann
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Developmental Biology
    2. Immunology and Inflammation

    Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

    Federico Andrea Moretti, Sarah Klapproth ... Markus Moser
    T cell progenitor homing into the thymus requires kindlin-3 to stabilize their adhesion to vascular integrin ligands when blood flow velocities and shear rates increase during development.
    1. Neuroscience

    Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

    Barbara Commisso, Lingjun Ding ... Francesco Roselli
    The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.