Browse our Research Articles

Page 986 of 1,402
    1. Neuroscience

    Constraints on neural redundancy

    Jay A Hennig, Matthew D Golub ... Steven M Chase
    The distribution of redundant neural activity is coupled with task-relevant activity, which may limit the extent to which redundancy can be exploited by the brain for computation.
    1. Neuroscience

    Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae

    Wenxuan He, David Kemp, Tianying Ren
    Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl, Zeynep Hein ... Sebastian Springer
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel, Masashi Goto ... Diane M Simeone
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
    1. Cell Biology

    The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

    Rengasayee Veeraraghavan, Gregory S Hoeker ... Robert G Gourdie
    Structural and functional investigations identify a structural unit for ephaptic coupling in the heart, and provide the mechanistic basis for a novel strategy for the treatment of arrhythmias.
    1. Neuroscience

    Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

    Romain Durand-de Cuttoli, Sarah Mondoloni ... Alexandre Mourot
    In vivo deconstruction of reward-related behaviors with circuit and pharmacological specificity using designer, light-controllable nicotinic acetylcholine receptors.
    1. Neuroscience

    A neural-level model of spatial memory and imagery

    Andrej Bicanski, Neil Burgess
    The BB model explains spatial cognition in terms of interactions between specific neuronal populations, providing a common computational framework for the human neuropsychological and in vivo animal electrophysiological literatures.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The mobility of packaged phage genome controls ejection dynamics

    Alex Evilevitch
    Temperature and ionic conditions control the mechanical properties of virally encapsidated DNA and act as a switch between synchronized and desynchronized genome ejection dynamics in a phage population.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

    Rongbo Li, Ksenija Bernau ... Xin Sun
    Lineage tracing using a knockin Pdgfra-rtTA tool indicates distinct contributions of this cell lineage to myofibroblasts in normal development, fibrosis and bronchopulmonary dysplasia models.
    1. Neuroscience

    Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

    Michael A Gaffield, Matthew J M Rowan ... Jason M Christie
    In behaving mice, inhibition from molecular layer interneurons attenuates excitation of Purkinje cells by parallel fibers and suppresses their ability to enhance climbing fiber-triggered dendritic Ca2+ responses.