Browse our Research Communication

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    1. Microbiology and Infectious Disease

    Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

    Elizabeth A Mueller et al.
    Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic et al.
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
    1. Neuroscience

    Extrinsic and intrinsic dynamics in movement intermittency

    Damar Susilaradeya et al.
    The rhythmicity in upper-limb tracking movements and associated population dynamics in primary motor cortex is explained by a feedback controller incorporating optimal state estimation.
    1. Cell Biology
    2. Developmental Biology

    Patronin governs minus-end-out orientation of dendritic microtubules to promote dendrite pruning in Drosophila

    Yan Wang et al.
    A minus-end-binding stabilizes minus-end-out microtubules in dendrites, which are required for dendrite-specific pruning during neuronal remodelling.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

    Mashaal Sohail et al.
    Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Reduced signal for polygenic adaptation of height in UK Biobank

    Jeremy J Berg et al.
    Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
    1. Developmental Biology
    2. Evolutionary Biology

    The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

    Suparna Ray et al.
    mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang et al.
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
    1. Microbiology and Infectious Disease

    Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

    Eva S Istvan et al.
    The malaria parasite Niemann-Pick Type C1-related protein is an important new antimalarial target.
    1. Genetics and Genomics

    Environmentally-induced epigenetic conversion of a piRNA cluster

    Karine Casier et al.
    Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.