Browse our Tools and Resources

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    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Taxonium, a web-based tool for exploring large phylogenetic trees

    Theo Sanderson
    A new tool allows researchers to dive into phylogenetic trees containing millions of nodes using just their web browser.
    1. Neuroscience

    A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology

    Benjamin FN Campbell, Antje Dittmann ... Shiva K Tyagarajan
    Anti-gephyrin synthetic protein binders were screened and developed to specifically and robustly detect gephyrin protein and gephyrin-interacting protein partners in the mouse brain, generating a useful tool set for neuroscience.
    1. Neuroscience

    Molecular and anatomical characterization of parabrachial neurons and their axonal projections

    Jordan L Pauli, Jane Y Chen ... Richard D Palmiter
    A guide summarizing the diversity of cell types in the parabrachial nucleus.
    1. Neuroscience

    In situ X-ray-assisted electron microscopy staining for large biological samples

    Sebastian Ströh, Eric W Hammerschmith ... Adrian Andreas Wanner
    In situ X-ray imaging of biological tissue samples in staining solution while they are being processed for electron microscopy reveals novel insights into the diffusion-reaction kinetics, tissue mechanics, and staining quality.
    1. Immunology and Inflammation

    Histone H3 clipping is a novel signature of human neutrophil extracellular traps

    Dorothea Ogmore Tilley, Ulrike Abuabed ... Arturo Zychlinsky
    Proteolytic events targeting histones can be harnessed to develop antibodies for neutrophil extracellular traps, improving researchers’ ability to distinguish these chromatin-based structures in human samples.
    1. Cell Biology

    Crosshair, semi-automated targeting for electron microscopy with a motorised ultramicrotome

    Kimberly Meechan, Wei Guan ... Yannick Schwab
    A new method using a motorised ultramicrotome and open-source software allows semi-automatic targeting of regions of interest for electron microscopy.
    1. Cell Biology
    2. Genetics and Genomics

    Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

    Peter S Johnstone, Maite Ogueta ... Deniz Top
    Locally activatable bioluminescence (LABL) is a genetically encoded reporter that allows real time, in vivo measurement of distinct clocks in different cells and tissues in Drosophila.
    1. Neuroscience

    Robotic multi-probe single-actuator inchworm neural microdrive

    Richard D Smith, Ilya Kolb ... Mladen Barbic
    A novel micropositioning approach allows remote-controlled, micrometer-resolution actuation of many densely packed, arbitrarily shaped probes with a device whose size and weight scale much more efficiently with probe count compared to current methods.
    1. Neuroscience

    Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons

    Viktor J Oláh, Nigel P Pedersen, Matthew JM Rowan
    Artificial neural networks can faithfully recapitulate realistic neuronal behavior with dramatically accelerated simulation runtimes, empowering accessible large-scale realistic network simulations.
    1. Developmental Biology
    2. Neuroscience

    A dynamic and expandable digital 3D-atlas maker for monitoring the temporal changes in tissue growth during hindbrain morphogenesis

    Matthias Blanc, Giovanni Dalmasso ... Cristina Pujades
    The digital 3D-atlas maker will help ascribing neuronal birthdate and neuronal differentiation times upon gene disruption in zebrafish avatars for human diseases, and will allow the integration of the information generated in other laboratories.