Animal G-protein-coupled bistable rhodopsins can regulate Gq- and Gi-mediated signaling in a light-dependent manner in neurons and cardiomyocytes, making them useful for analyzing the roles of GPCR signaling in vivo.
Alexandre P Thiery, Ailin Leticia Buzzi ... Andrea Streit
Neural plate border cells co-express neural, neural crest, and placodal transcriptional programs before cell fate decisions occur and are transcriptionally heterogeneous along the antero-posterior and medial-lateral axis.
To study odor-guided navigation of small animals such as worms and fly larvae, a novel flow chamber and odor sensor array are presented that better characterize the odors that the animal experiences.
Brijesh Modi, Matteo Guardamagna ... Francesco P Battaglia
A novel analytical framework for investigation of simultaneously occurring brain oscillations (from either single or multiple brain areas) and how it modulates the underlying neuronal population during sleep and wakefulness (or other behavioral tasks).
Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
Advanced computational processing and analysis of functional MRI create the first comprehensive set of high-resolution cortical parcellations maps of infant brains.
The BABY algorithm by estimating growth rates of individual cells from time-lapse microscopy images will help characterise the diversity in populations of budding cells, particularly differences in fitness.
Development of an enrichment method to facilitate RNA-sequencing of the Lyme disease pathogen from inside of ticks during a bloodmeal provides new candidates for genes important for disease transmission.
Eike K Mahlandt, Sebastián Palacios Martínez ... Joachim Goedhart
Optogenetic activation of Rho GTPases provides spatiotemporal control over endothelial cell shape and enables control over endothelial barrier function by manipulating the cell-cell overlap with blue light.
