Browse our Tools and Resources

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    1. Developmental Biology
    2. Neuroscience

    A dynamic and expandable digital 3D-atlas maker for monitoring the temporal changes in tissue growth during hindbrain morphogenesis

    Matthias Blanc, Giovanni Dalmasso ... Cristina Pujades
    The digital 3D-atlas maker will help ascribing neuronal birthdate and neuronal differentiation times upon gene disruption in zebrafish avatars for human diseases, and will allow the integration of the information generated in other laboratories.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Delineating the transcriptional landscape and clonal diversity of virus-specific CD4+ T cells during chronic viral infection

    Ryan Zander, Achia Khatun ... Weiguo Cui
    CD4+ T cells responding to chronic lymphocytic choriomeningitis virus infection display transcriptional heterogeneity that is marked by both lineage-specific gene expression profiles and core gene expression programs that are upregulated and conserved across multiple distinct populations of T helper cells.
    1. Developmental Biology

    Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii

    Jennifer McKey, Dilara N Anbarci ... Blanche Capel
    A detailed characterization of mouse ovary development using tissue clearing and 3D lightsheet imaging identifies ovary folding, specification of cortical and medullary domains, and ovary encapsulation as major hallmarks of ovary morphogenesis.
    1. Neuroscience
    2. Physics of Living Systems

    Mathematical relationships between spinal motoneuron properties

    Arnault H Caillet, Andrew TM Phillips ... Luca Modenese
    Validated mathematical relationships between motoneuron morphometric and electrophysiological properties are provided as a tool for neuroscientists and modellers to generate hypotheses for experimental studies investigating currently unreported relationships and build virtual motoneuron profiles with consistent properties for modelling purposes.
    1. Computational and Systems Biology
    2. Neuroscience

    CompoundRay, an open-source tool for high-speed and high-fidelity rendering of compound eyes

    Blayze Millward, Steve Maddock, Michael Mangan
    Rendering compound vision at high speed with high precision, enabling rapid, data-driven exploration of the compound eye design space.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Little skate genome provides insights into genetic programs essential for limb-based locomotion

    DongAhn Yoo, Junhee Park ... Myungin Baek
    The generation of high-quality little skate reference genome enables molecular mechanism studies of gene regulation.
    1. Epidemiology and Global Health
    2. Medicine

    The ellipse of insignificance, a refined fragility index for ascertaining robustness of results in dichotomous outcome trials

    David Robert Grimes
    An ellipse of insignificant analysis is a robust method for ascertaining the strength of even large dichotomous outcome trials in biomedical science, and is a novel means to detect potentially dubious results and research fraud.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Highly efficient generation of isogenic pluripotent stem cell models using prime editing

    Hanqin Li, Oriol Busquets ... Frank Soldner
    A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

    Dirk H Siepe, Lukas T Henneberg ... K Christopher Garcia
    A proteo-genomic CRISPR activation screening workflow to accelerate the identification of novel interactions between the secreted and membrane proteome with the potential to define new biological processes and identify future therapeutic targets.
    1. Ecology
    2. Evolutionary Biology

    Species clustering, climate effects, and introduced species in 5 million city trees across 63 US cities

    Dakota E McCoy, Benjamin Goulet-Scott ... John Kartesz
    Across 63 large US cities, street tree communities are shaped by climate, clustered by species, and made more similar between cities due to the presence of introduced species.