Browse our Tools and Resources

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    1. Plant Biology

    Increased signal-to-noise ratios within experimental field trials by regressing spatially distributed soil properties as principal components

    Jeffrey C Berry, Mingsheng Qi ... Rebecca S Bart
    A method to reduce the noise present in field experiments by accounting for heterogeneity in field soils.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

    Lewis Macdonald, Gillian C Taylor ... Andrew J Wood
    Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.
    1. Neuroscience

    Long-term transverse imaging of the hippocampus with glass microperiscopes

    William T Redman, Nora S Wolcott ... Michael J Goard
    Two-photon imaging through glass microperiscopes allows imaging of the transverse plane of the hippocampus, including all major subfields, in awake behaving mice.
    1. Computational and Systems Biology
    2. Neuroscience

    Waveform detection by deep learning reveals multi-area spindles that are selectively modulated by memory load

    Maryam H Mofrad, Greydon Gilmore ... Lyle Muller
    A new computational approach for detecting sleep waveforms reveals that the 11–15 Hz sleep 'spindle', a neural rhythm implicated in memory consolidation, co-occurs widely across cortex much more often than previously thought.
    1. Immunology and Inflammation

    Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

    Laura Medina-Ruiz, Robin Bartolini ... Gerard J Graham
    The use of multi-chemokine receptor reporter mice helps to unravel the dynamics of receptor involvement in leukocyte migration in vivo and suggests specificity, rather than redundancy, in receptor use.
    1. Neuroscience

    Minian, an open-source miniscope analysis pipeline

    Zhe Dong, William Mau ... Denise J Cai
    Minian is an open-source analysis pipeline for calcium imaging data that enhances usability with low memory demands and transparency with user-friendly interactive visualizations.
    1. Neuroscience

    Partial response electromyography as a marker of action stopping

    Liisa Raud, Christina Thunberg, René J Huster
    Partial response electromyography is a useful and reliable measure of action stopping in a stop signal task, supported by psychometric and meta-analytic evidence.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members

    Jakub Gemperle, Thomas S Harrison ... Patrick T Caswell
    DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Bayesian machine learning analysis of single-molecule fluorescence colocalization images

    Yerdos A Ordabayev, Larry J Friedman ... Douglas L Theobald
    A physics-based, statistically rigorous mathematical model enables automated, objective interpretation of images from single-molecule fluorescence colocalization microscopy experiments.
    1. Medicine
    2. Neuroscience

    Lead-OR: A multimodal platform for deep brain stimulation surgery

    Simón Oxenford, Jan Roediger ... Andreas Horn
    Lead-OR visualizes results derived from microelectrode recordings in anatomical space, together with information derived from patient-specific MRI data, as well as high-resolution atlas resources during deep brain stimulation surgery.