Browse our Tools and Resources

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    1. Neuroscience

    The OpenNeuro resource for sharing of neuroscience data

    Christopher J Markiewicz, Krzysztof J Gorgolewski ... Russell Poldrack
    OpenNeuro is a data sharing archive that provides a platform for the free and open sharing of a broad range of neuroscience data types.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing

    Zelin Liu, Changyu Tao ... Ence Yang
    Accurate identification and quantification of various circRNA isoforms.
    1. Cell Biology

    Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids

    Patrick C Hoffmann, Stefano L Giandomenico ... Wanda Kukulski
    Combining cerebral organoid technology with cryo-correlative microscopy reveals the organization of cytoskeleton, membrane compartments, and protein synthesis machinery contributing to the rapid expansion of developing human axons.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Multicolor fluorescence fluctuation spectroscopy in living cells via spectral detection

    Valentin Dunsing, Annett Petrich, Salvatore Chiantia
    Fluorescence fluctuation spectroscopy is implemented for detection of up to four molecular species, allowing users to quantify molecular interactions and stoichiometry of multicomponent complexes in live cells, in a wide range of biological processes, from membrane signaling to viral assembly.
    1. Neuroscience

    A state space modeling approach to real-time phase estimation

    Anirudh Wodeyar, Mark Schatza ... Mark A Kramer
    A statistically principled approach developed to estimate phase of rhythmic signals in real-time shows robustness to multiple sources of error and also provides confidence criteria.
    1. Neuroscience

    Proof of concept for multiple nerve transfers to a single target muscle

    Matthias Luft, Johanna Klepetko ... Konstantin Davide Bergmeister
    A murine model for a novel surgical concept demonstrates potential advances of neuroprosthetic interfacing.
    1. Neuroscience

    Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

    Carlos G Moreira, Christian R Baumann ... Daniela Noain
    Delivery of auditory triggers as unique slow waves-targeting approach yields efficient, stable, and precise modulation of slow-wave activity in rats.
    1. Neuroscience

    An open-source, high-performance tool for automated sleep staging

    Raphael Vallat, Matthew P Walker
    A robust automatic sleep-staging algorithm offers a high level of accuracy matching that of typical human interscorer agreement.
    1. Computational and Systems Biology

    Simplifying the development of portable, scalable, and reproducible workflows

    Stephen R Piccolo, Zachary E Ence ... Andrea H Bild
    Descriptions, examples, and tools to enable biologists to use the Common Workflow Language for data processing and to facilitate computational reproducibility.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET

    William N Zagotta, Brandon S Sim ... Sharona E Gordon
    Time-resolved transition metal ion fluorescence resonance energy transfer using a fluorescent, noncanonical amino acid donor and metal ion acceptor measures distances and distance distributions in proteins, allowing the equilibrium distributions among conformational states to be accurately determined.