The proposed method deciphers which low-level patterns (such as spikes) control high-level features (behavior) in relative small biological datasets, taking into account the statistical dependencies between such patterns.
Lisa L Kirkemo, Susanna K Elledge ... James A Wells
Enzyme tethering of promiscuous biotinylators to the cell surface allows for more rapid and efficient comparative surface proteomic analysis of cells and extracellular vesicles.
Giorgio Oliviero, Sergey Kovalchuk ... Ole N Jensen
Quantitative proteomics reveals the diversity and heterogeneity of nuclear proteomes in mammalian organs and identifies the molecular features of ageing.
Korin Sahinyan, Darren M Blackburn ... Vahab D Soleimani
Single myofiber ATAC-Seq provides assessment of chromatin accessibility of a single myofiber without the confounding effects of other cell types present in skeletal muscle.
Ten-fold Robust Expansion Microscopy (TREx) is a new method for 10-fold physical expansion of specimens in one round of gel embedding, enabling nanoscale imaging of antibody stains and ultrastructural detail.
The in vitro and in vivo characterization of two nanobody/NanoTag pairs in the Drosophila system provides a variety of assays for protein detection and manipulation.
Development of imaging methods to capture neural activity and structure through the intact cuticle using 2-photon and 3-photon excitation in the genetic model organism, Drosophila melanogaster.
Clare M Smith, Richard E Baker ... Christopher M Sassetti
A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.
Marie Francois, Isabella Canal Delgado ... Lori Zeltser
Systematic testing of experimental variables in a common neurobehavioral paradigm revealed that conditions that more closely match human physiology reliably elicit stress eating in mice.
