Browse the latest research

Page 2 of 1,793
    1. Genetics and Genomics
    2. Evolutionary Biology

    Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early Infection

    Dayeon Lee, Sin Young Choi ... Jihwan Park
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    A Novel Mouse Model for LAMA2-Related Muscular Dystrophy: Analysis of Molecular Pathogenesis and Clinical Phenotype

    Dandan Tan, Yidan Liu ... Hui Xiong
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Developmental Biology

    Evolution of lateralized gustation in nematodes

    Marisa Mackie, Vivian Vy Le ... Ray L Hong
    A comparison of how two nematode species sense salts highlights how evolution can find different ways to establish asymmetry in small nervous systems to optimize the processing of chemosensory cues.
    1. Neuroscience

    Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

    Matthew Davenport, Ha Na Choe ... Erich Jarvis
    Hormonal manipulation, laser microdissection, and bulk RNA sequencing indicate that Z chromosome dosage in the brain region HVC during development regulates the subsequent sexually dimorphic transcriptional specialization of zebra finch song nuclei.
    1. Neuroscience

    Effects of experiencing the COVID-19 pandemic on optimistically biased belief updating

    Iraj Khalid, Orphee Morlaas ... Liane Schmidt
    Exposure to a real-life adversity, such as the COVID-19 pandemic, reduced the optimism bias typically observed in belief updating about future life events, shifting behavior toward more rational, Bayesian-like learning.
    1. Structural Biology and Molecular Biophysics

    Expanding automated multiconformer ligand modeling to macrocycles and fragments

    Jessica Flowers, Nathaniel Echols ... Stephanie A Wankowicz
    qFit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).
    1. Computational and Systems Biology

    Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

    David Dierks, Ran Shachar ... Schraga Schwartz
    A quantitative model explains intra- and intercellular changes in m6A gene methylation as passive consequences of mRNA metabolism.
    1. Neuroscience

    Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    Adam Glaser, Jayaram Chandrashekar ... Karel Svoboda
    Large-scale microscopy combined with tissue clearing and expansion enables nanoscale imaging of centimeter scale specimens.
    1. Immunology and Inflammation

    CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration

    Zhiyuan Wu, Lindi Liu ... Xiaodong Tan
    CD131 contributes to intestinal inflammation in ulcerative colitis, possibly by promoting the infiltration of macrophages, while targeting CD131 might potentially be a treatment remedy for ulcerative colitis.