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Chemotherapy remodels lung adenocarcinoma’s tumor microenvironment by driving metabolic reprogramming and shifting immune cell functions to modulate tumor progression and immune responses.

Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.

The TIPE/PKM2/HIF-1α signaling pathway plays a crucial role in enhancing cancer stem cell properties by facilitating glycolysis, thereby presenting a promising therapeutic target for melanoma intervention.

The detection of low quantities of alkaloids in putatively nontoxic species of poison frogs sheds light on early evolutionary stages of chemical defense in animals.

NMR and clustering results show that N-terminal acetylation of α-syn enhances its binding to the neutral phospholipid lysophosphatidylcholine, thereby promoting its function of clustering synaptic vesicles.

Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.

A genetic screen and combined bioinformatic analyses revealed multiple novel transcription factors and their hierarchical organization in coordinating mitochondrial biogenesis.

Reinforcement learning produces long-lasting realignment of layer 1 apical dendrite tuft responses to behaviorally relevant task dimensions, both rewarded and unrewarded.

The clinically approved BTK kinase active site inhibitors alter the conformational equilibrium of full-length BTK in distinct and unexpected ways.