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    1. Microbiology and Infectious Disease

    Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

    Yang Fu, Xiao-Dan Luo ... Wence Wang
    Lactobacillus plantarum regulates host uric acid metabolism via its own nucleoside hydrolase iunH.
    1. Cell Biology

    PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

    Weihong Xiong, Maozhen Qin, Haining Zhong
    Two alternative models of PKA activation were tested in neurons, and the results support the classical model in which the catalytic subunit dissociated from the regulatory subunit upon activation.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Immunology and Inflammation

    CD131 Contributes to Ulcerative Colitis Pathogenesis by Promoting Macrophage Infiltration

    Zhiyuan Wu, Lindi Liu ... Xiaodong Tan
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Microbiology and Infectious Disease

    Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity

    Sasmita Panda, Yahani P Jayasinghe ... Vinai C Thomas
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Characterizing the Spatial Distribution of Dendritic RNA at Single Molecule Resolution

    Jihoon Kim, Jean G Rosario ... Junhyong Kim
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments

    Chad Heer, Mark Sheffield
    In the CA1 region of the hippocampus, VTA inputs signal reward proximity while LC inputs respond to novelty, illustrating distinct catecholaminergic roles in hippocampal processing during navigation and learning.
    1. Developmental Biology

    Inhibition of the Notch signal transducer CSL by Pkc53E-mediated phosphorylation to fend off parasitic immune challenge in Drosophila

    Sebastian Deichsel, Lisa Frankenreiter ... Anja C Nagel
    Pkc53E kinase-mediated downregulation of CSL/Su(H) activity is a direct molecular response to parasitoid wasp infestation in Drosophila, allowing the differentiation of encapsulation-active lamellocytes, thereby ensuring an appropriate immune defense.
    1. Structural Biology and Molecular Biophysics

    Functional implications of the exon 9 splice insert in GluK1 kainate receptors

    Surbhi Dhingra, Prachi M Chopade ... Janesh Kumar
    GluK1-1 splice variant alters the gating properties of kainate receptors, providing crucial insights into receptor modulation by auxiliary proteins and advancing the understanding of synaptic transmission.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

    Rebecca Warfvinge, Linda Geironson Ulfsson ... Göran Karlsson
    Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.
    1. Genetics and Genomics

    DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

    Xiang Wang, Gan Shen ... Ying Shen
    DNAH3 is a novel pathogenic gene of male infertility and plays essential role in flagellar IDA assembly in humans and mice.