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    1. Cell Biology
    2. Genetics and Genomics

    Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

    Priyanka Das, Alejandro Aballay, Jogender Singh
    Calcineurin inhibition has opposing effects on Caenorhabditis elegans lifespan and survival on pathogens via its role in the defecation motor program.
    1. Neuroscience

    Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct

    Giordano de Guglielmo, Lieselot Carrette ... Olivier George
    Genetically diverse rats reveal a single underlying construct linking key addiction-like behaviors, challenging compulsivity as an independent measure, and offering a new perspective on vulnerability and resilience to addiction.
    1. Cell Biology

    Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

    Jessica E Schwarz, Antonijo Mrčela ... Amita Sehgal
    Blood-borne factors contribute to changes in the circadian transcriptome with age.
    Version of Record
    Short Report
    • Fundamental
    • Compelling
    1. Neuroscience

    Comparative neuroimaging of the carnivoran brain: Neocortical sulcal anatomy

    Magdalena Boch, Katrin Karadachka ... Rogier B Mars
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development

    Sharvani Mahadevaraju, Soumitra Pal ... Brian Oliver
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology

    Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

    Xinlei Cai, Yi Ye ... Hongbin Ji
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    RNase III in Salmonella Enteritidis enhances bacterial virulence by reducing host immune responses

    Bill Kwan-wai Chan, Yingxue Li ... Sheng Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury

    Tingting Li, Wenwen Shi ... Yong Q Zhang
    Upon traumatic brain injury in Drosophila adults, a previously unknown Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes.
    1. Plant Biology

    Structural basis for molecular assembly of fucoxanthin chlorophyll a/c-binding proteins in a diatom photosystem I supercomplex

    Koji Kato, Yoshiki Nakajima ... Ryo Nagao
    The molecular mechanisms of FCPI assembly and selective binding are revealed through comparison of PSI-FCPI structures in two diatom species.
    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
    Polyunsaturated fatty acids activate IKs channels by stabilizing a conductive state of the selectivity filter.
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