Quantitative models for responses of rod and cone photoreceptors are developed that allow direct tests of the impact of the photoreceptors on responses of downstream visual neurons.
Sebastian Quiroz Monnens, Casper Peters ... Bernhard Englitz
The recurrent temporal restricted Boltzmann machine applied to whole-brain neuronal recordings from larval zebrafish brains provides substantial advantages in discovering the neuronal assembly structure and their connectivity.
Targeted memory reactivation improved memory performance of easy-to-learn words, but had no effect of difficult-to-learn words, which suggests a critical role of word learning difficulty in sleep associated memory reactivation.
SIRT4 regulates cellular communication network factor 2 expression through U2 small nuclear RNA auxiliary factor 2-mediated pre-mRNA splicing, presenting a potential therapeutic target for kidney fibrosis.
By harnessing antibody fragments conjugated to small gold nanoparticles together with high pressure freezing, FIB/SEM milling and cryo-electron tomography, AMPA receptors were identified from mouse brain tissue.
Galectin-9 directly binds to arabinogalactan (AG), leading to the identification of AG-specific monoclonal antibodies that effectively inhibit Mycobacterium tuberculosis growth, providing insights for novel tuberculosis therapies.
Anna Herrmannová, Jan Jelínek ... Leoš Shivaya Valášek
eIF3, despite being a general translation initiation factor, functions in mRNA-specific regulation, having a profound impact on the synthesis and activation of the MAPK pathway components and ribosomal proteins.
Sex differences in the age-related decline of blood-brain barrier function vary across brain regions, with a more pronounced decrease observed in males beginning in the early 60s.
Allison T Goldstein, Terrence R Stanford, Emilio Salinas
Psychophysical measurements using time pressure indicate that when attention is willfully deployed, a congruent scaccade is automatically planned, but the coupling is weak and can be rapidly broken.
