Browse the latest research

Page 218 of 1,799
    1. Ecology

    Contrasting responses to aridity by different-sized decomposers cause similar decomposition rates across a precipitation gradient

    Viraj R Torsekar, Nevo Sagi ... Dror Hawlena
    Contrasting climatic dependencies of macrofauna and microorganisms generate similar whole-community decomposition rates across a precipitation gradient, plausibly resolving the longstanding puzzle of why arid-land litter decomposition is decoupled from precipitation.
    1. Biochemistry and Chemical Biology

    Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110

    Wiktoria Sztangierska, Hubert Wyszkowski ... Agnieszka Kłosowska
    Recovery of proteins from aggregates by Hsp70 is boosted by the Hsp110 co-chaperone, which promotes abundant Hsp70 recruitment to aggregates and supports initial aggregate remodelling into small assemblies.
    1. Neuroscience

    Ih block reveals separation of timescales in pyloric rhythm response to temperature changes in Cancer borealis

    Kyra Schapiro, JD Rittenberg ... Eve Marder
    The hyperpolarization-activated inward current plays an important role in regulating both smooth transitory responses and persistent increases in pyloric frequency during temperature fluctuations in Cancer borealis.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Light-driven synchronization of optogenetic clocks

    Maria Cristina Cannarsa, Filippo Liguori ... Roberto Di Leonardo
    Introducing the optorepressilator, a synthetic genetic oscillator that can be synchronized, entrained, and detuned by green light to precisely control periodic gene expression in single cells or entire bacterial populations.
    1. Chromosomes and Gene Expression

    Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes

    Linda S Rubio, Suman Mohajan, David S Gross
    In response to ethanol stress, the yeast transcription factor Hsf1 forms nuclear condensates and drives the coalescence of target genes prior to their transcriptional activation while in response to thermal stress these three phenomena are tightly coordinated.
    1. Developmental Biology

    Permissive and instructive Hox codes govern limb positioning

    Yajun Wang, Maik Hintze ... Ruijin Huang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Incomplete
    1. Computational and Systems Biology
    2. Cancer Biology

    Is tumor mutational burden predictive of response to immunotherapy?

    Carino Gurjao, Dina Tsukrov ... Leonid A Mirny
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Immunology and Inflammation

    Mast cells promote pathology and susceptibility in tuberculosis

    Ananya Gupta, Vibha Taneja ... Shabaana A Khader
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    A comparative study of the cryo-EM structures of Saccharomyces cerevisiae and human anaphase-promoting complex/cyclosome (APC/C)

    Ester Vazquez-Fernandez, Jing Yang ... David Barford
    The yeast APC/C cryo-EM structure reveals substantial similarities with the human APC/C structure but also important differences in mechanisms of phosphorylation-dependent regulation and activation by coactivators.