Johannes Oppermann, Andrey Rozenberg ... Peter Hegemann
Engineered anion-conducting channelrhodopsins with enhanced red-light sensitivity and accelerated kinetics enable precise, low-intensity optical silencing of neurons, advancing optogenetic control in neuroscience research.
Design and characterization of allosteric mutations that recapitulate TRPML1 gating and structural insights into PI(4,5)P2 and sphingomyelin inhibition of TRPML1.
A multi-disciplined approach uncovered microRNA-199a/b-5p as important regulators of chondrogenesis, which negatively regulate mRNAs such as FZD6, ITGA3, and CAV1 for protective purposes during chondrogenesis.
Intact and local emotional biological motion exerted distinct influences on pupil responses, wherein the emotional modulation observed in intact biological motion is linked to individual autistic traits.
Archana Kamalakar, Brendan Tobin ... Steven L Goudy
Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.
Ilya A Rybak, Natalia A Shevtsova ... Alain Frigon
Spinal circuits performing speed- and context-dependent control of locomotion in mammals can operate in different regimes with prevailing role of central mechanisms, supraspinal signals, or sensory feedback.
A single-cell RNA sequencing reveals cell heterogeneity of secondary metabolism in tea plant root and a proposed model in which the theanine biosynthesis pathway occurs via multicellular compartmentation.
Cell-cell interaction between neural crest-derived cells and mesoderm-derived cells determine cell fate of mesoderm-derived cell in tongue development through Hh signaling.
