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    1. Genetics and Genomics

    Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription

    Chaïma Azouzi, Katrin Schwank ... Christophe Dez
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

    J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

    Chengrui Shi, Chaofei Su ... Hang Yin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Güller ... Jan-Wilhelm Kornfeld
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Age and learning shapes sound representations in auditory cortex during adolescence

    Benedikt Praegel, Feng Chen ... Adi Mizrahi
    Weaker performance in adolescent mice arises from immature cortical representations and cognitive bias, linking developmental changes in behavior with underlying neural coding.
    1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon
    KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.
    1. Neuroscience

    Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates

    Gianpaolo Antonio Basile, Augusto Ielo ... Alberto Cacciola
    The pulvinar complex harbors multiple representations of cortico-cortical connectivity organized hierarchically across its ventro-dorsal and medio-lateral axes.
    1. Neuroscience

    Synchronous ensembles of hippocampal CA1 pyramidal neurons during novel exploration

    En-Li Chen, Tsai-Wen Chen ... Bei-Jung Lin
    CA1 pyramidal neurons exhibit synchronous spiking during movement and pauses in novel environments, reflecting a neural signature of spatial learning.
    1. Neuroscience

    Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness

    Guylaine Hoffner, Pablo Castro ... Béchir Jarraya
    The effects of transcranial direct current stimulation on cortical dynamics depend on the state of consciousness and the stimulation polarity.
    1. Cell Biology

    The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

    Ana Lapao, Lauren Sophie Johnson ... Anne Simonsen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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