Browse the latest research

Page 27 of 1,877
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Material Damage to Multielectrode Arrays after Electrolytic Lesioning is in the Noise

    Alice Tor, Stephen E Clarke ... Brain Interfacing Laboratory
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Developmental Biology

    Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration

    Jisheng Sun, Lu Chen, Jinhu Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    Fine-tuning of outer membrane–peptidoglycan tethering by the redox-active lipoprotein LppB from Salmonella enterica

    Elisa S Pierre Despas, Seung-Hyun Cho ... Jean-François Collet
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Solid
    1. Neuroscience

    Adjoint propagation of error signal through modular recurrent neural networks for biologically plausible learning

    Zhuo Liu, Hao Shu ... Tao Chen
    The adjoint propagation framework enables the concurrent flow of signals and errors, providing a biologically and physically plausible learning mechanism.
    1. Computational and Systems Biology

    Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

    Zhiwei Huang, Songhao Luo ... Jiajun Zhang
    DNA damage reshapes genome-wide transcriptional bursting, with distinct burst size and frequency programs associated with differentiation, apoptosis, and survival decisions.
    1. Cell Biology

    SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy

    Grace Essuman, Midhat Rizvi ... Emmanuelle Cordat
    Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Correction: Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

    Mounir El Maï, Marta Marzullo ... Miguel Godinho Ferreira
    1. Chromosomes and Gene Expression

    Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

    Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
    Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Contractile peri-nuclear actomyosin network repositions peripheral and polar chromosomes to promote early kinetochore–microtubule interactions

    Nooshin Sheidaei, John K Eykelenboom ... Tomoyuki U Tanaka
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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