Christian Galicia, Giambattista Guaitoli ... Wim Versées
Conformation-specific nanobodies enable to capture and solve the first GTP-bound active structure of a bacterial homolog of the Parkinson-associated LRRK2 protein, providing insights into the activation mechanism of these proteins.
An individual-based model framework of sub-exponentially growing replicator systems suggests that parabolic dynamics could have been able to maintain genetic diversity and circumvent the error threshold problem during early evolution.
Marcos Moreno-Aguilera, Alba M Neher ... Carme Gallego
KIS, a kinase upregulated in the developmental brain, phosphorylates the PTBP2 splicing complex and modulates alternative exon usage for proper synaptic spine emergence and maturation.
Sangeetha Kandoi, Cassandra Martinez ... Deepak A Lamba
Stem cell-derived retinal organoids are a useful tool to understand the pathobiology of devastating retinal degenerations and can aid to identify and validate therapeutics to promote rescue.
Experimental Piper gardens across five neotropical sites reveal complex contingencies in the influence of species and population-level biodiversity on the flow of resources to insect herbivores and ecosystem resilience to changes in water availability.
The distinct transcriptomic features of extraocular muscle satellite cells, partially mimicked by NaBu treatment, endow enhanced self-renewal and axon attraction, contribute to neuromuscular junction preservation during ALS progression.
Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
Sleep-encoded vocabulary influences awake decision-making 36 hr later, particularly when targeting the vocabulary to slow-wave troughs, which suggests that unconscious episodic memory formation during deep sleep is possible.
