Sangeetha Kandoi, Cassandra Martinez ... Deepak A Lamba
Stem cell-derived retinal organoids are a useful tool to understand the pathobiology of devastating retinal degenerations and can aid to identify and validate therapeutics to promote rescue.
Experimental Piper gardens across five neotropical sites reveal complex contingencies in the influence of species and population-level biodiversity on the flow of resources to insect herbivores and ecosystem resilience to changes in water availability.
The distinct transcriptomic features of extraocular muscle satellite cells, partially mimicked by NaBu treatment, endow enhanced self-renewal and axon attraction, contribute to neuromuscular junction preservation during ALS progression.
Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
Sleep-encoded vocabulary influences awake decision-making 36 hr later, particularly when targeting the vocabulary to slow-wave troughs, which suggests that unconscious episodic memory formation during deep sleep is possible.
Simona Bolamperti, Hiroaki Saito ... Hanna Taipaleenmäki
A novel mechanism underlying the regulation of osteoblast morphology, adherence, and migration that has implications in bone remodeling, regeneration, and response to the pharmacological effects of PTH treatment.
Alexander D Cook, Mark Carrington, Matthew K Higgins
A structure derived from cryogenic electron microscopy shows how ISG65, an African trypanosome receptor that aids virulence, binds C3b and suggests mechanisms through which ISG65 might aid complement resistance.
Alyssa D Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
Glutamatergic–cholinergic neurons in the postinspiratory complex are critical for swallow motor patterning and the coordination of swallow and breathing, which is disrupted by chronic intermittent hypoxia, a condition seen in many disorders associated with dysphagia and aspiration pneumonia.
Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.
Differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance hemodialysis subjects are comparable to healthy controls and identify transcriptomic and clinical predictors of anti-spike IgG titers in hemodialysis subjects.
