Browse the latest research

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    1. Ecology

    Deciphering deep-sea chemosynthetic symbiosis by single-nucleus RNA-sequencing

    Hao Wang, Kai He ... Chaolun Li
    A cellular map of a deep-sea mussel gill unveils how distinct cell types collaborate to cultivate intracellular symbiotic bacteria, providing insights into host–symbiont interactions and environmental adaptation in bivalves.
    1. Cell Biology
    2. Neuroscience

    Combining array tomography with electron tomography provides insights into leakiness of the blood-brain barrier in mouse cortex

    Georg Kislinger, Gunar Fabig ... Martina Schifferer
    An array tomography and electron tomography hybrid approach based on coated plastic tape as support advances ultrastructural analysis of biological phenomena that require cell- and tissue-level contextualization of the finest subcellular textures.
    1. Neuroscience

    Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals

    Wenyu Tu, Samuel R Cramer, Nanyin Zhang
    There is a disparity in temporal and spatial relationships between resting-state electrophysiological and functional magnetic resonance imaging (fMRI) signals, suggesting the electrophysiological signal alone cannot fully explain the effects observed in the resting-state fMRI signal.
    1. Computational and Systems Biology

    Convergent evolution in silico reveals shape and dynamic principles of directed locomotion

    Renata B Biazzi, André Fujita, Daniel Y Takahashi
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Plant Biology

    Subcellular visualization of the distribution of atmospheric dinitrogen fixed by Gluconacetobacter diazotrophicus bacteria in maize

    Greg McMahon, Stephanie Rey ... Edward Cocking
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

    Danielle Algranati, Roni Oren ... Efrat Shema
    Combined inhibition of oncogenic and epigenetic pathways results in a substantial decrease in the viability and growth of H3-K27M pediatric glioma models.
    1. Cell Biology

    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

    KC Farrell, Jennifer T Wang, Tim Stearns
    Centrosomes in mammalian cells are required for timely completion of mitosis and in their absence the spindle assembly checkpoint is required to delay mitosis and allow assembly of a functional spindle.
    1. Microbiology and Infectious Disease

    Metabolic disruption impairs ribosomal protein levels, resulting in enhanced aminoglycoside tolerance

    Rauf Shiraliyev, Mehmet A Orman
    Aminoglycoside tolerance in tricarboxylic acid cycle and electron transport chain mutants does not result from impaired proton motive force and altered drug uptake, but rather from the downregulation of ribosomal proteins, which are primary targets of this drug class.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Deciphering the actin structure-dependent preferential cooperative binding of cofilin

    Kien Xuan Ngo, Huong T Vu ... Taro Uyeda
    HS-AFM and Principal Component Analysis provide experimental evidence to substantiate the 'proof of principle' regarding the flexible helical twists of actin filaments that regulate the functions of actin-binding proteins.