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    1. Physics of Living Systems

    Growth consequences of the inhomogeneous organization of the bacterial cytoplasm

    Johan H van Heerden, Alicia Berkvens ... Frank J Bruggeman
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Differential conformational dynamics in two type-A RNA-binding domains drive the double-stranded RNA recognition and binding

    Firdousi Parvez, Devika Sangpal ... Jeetender Chugh
    The differential conformational space accessible to the two domains of TRBP, even though they both adopt a canonical dsRBD fold, affect how they interact with target RNAs.
    1. Chromosomes and Gene Expression

    Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

    Xinyang Bing, Wenfan Ke ... James B Jaynes
    Boundary:boundary pairing interactions drive TAD formation in Drosophila.
    1. Immunology and Inflammation
    2. Neuroscience

    Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice

    Nicolas Aubert, Madeleine Purcarea ... Gilles Marodon
    Regulatory T cells produce analgesic opioid peptides that limit heat sensitivity in mice, revealing a novel pain regulation mechanism independent of inflammation control.
    1. Chromosomes and Gene Expression

    Stem-loop and circle-loop TADs generated by directional pairing of boundary elements have distinct physical and regulatory properties

    Wenfan Ke, Miki Fujioka ... James B Jaynes
    Boundary:boundary pairing generates either stem-loop or circle-loop TADs, and these loop topologies differ in how they impact chromosome structure and genetic activities.
    1. Neuroscience

    Signatures of Bayesian inference emerge from energy-efficient synapses

    James Malkin, Cian O'Donnell ... Laurence Aitchison
    The parallels between Bayesian synapses and energy-efficient synapses are highlighted.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ORP9-ORP11 dimer promotes sphingomyelin synthesis

    Birol Cabukusta, Shalom Borst Pauwels ... Jacques Neefjes
    Lipid transfer proteins at the ER-Golgi interface synchronize intracellular lipid flows through the secretory pathway, ensuring the asymmetric lipid composition of the plasma membrane.
    1. Structural Biology and Molecular Biophysics

    Plasticity of the proteasome-targeting signal Fat10 enhances substrate degradation

    Hitendra Negi, Aravind Ravichandran ... Ranabir Das
    Biophysical experiments, pulse-chase assays, and molecular dynamics simulations reveal how the proteasome targeting signal Fat10 can modulate the structure of substrate proteins to potentially regulate their degradation by the proteasome.
    1. Computational and Systems Biology

    Alleviating cell-free DNA sequencing biases with optimal transport

    Antoine Passemiers, Tatjana Jatsenko ... Yves Moreau
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    A multiscale model of striatum microcircuit dynamics

    Federico Tesler, Alexander Kozlov ... Alain Destexhe
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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