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    1. Cell Biology
    2. Immunology and Inflammation

    Stimulation-induced cytokine polyfunctionality as a dynamic concept

    Kevin Portmann, Aline Linder, Klaus Eyer
    Resolving parallel and concurrent cytokine secretion is essential to studying polyfunctional cytokine-secreting cells, and to differentiating immune response granularity from unwinding the complexity and heterogeneity of cytokine responses.
    1. Neuroscience

    Mapping responses to focal injections of bicuculline in the lateral parafacial region identifies core regions for maximal generation of active expiration

    Annette Pisanski, Mitchell Prostebby ... Silvia Pagliardini
    Multivariate analysis of respiratory cycle shows that GABAergic disinhibition in the rostral regions of the lateral parafacial area is linked to the most significant and enduring changes in active expiration.
    1. Neuroscience

    Modulation of alpha oscillations by attention is predicted by hemispheric asymmetry of subcortical regions

    Tara Ghafari, Cecilia Mazzetti ... Ole Jensen
    Lateral asymmetry of the globus pallidus, caudate nucleus, and thalamus can predict attention-related modulations of posterior alpha oscillations when combining structural MRI with MEG.
    1. Neuroscience

    Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons

    Ricardo Raudales, Gukhan Kim ... Z Josh Huang
    A lineage-based intersectional genetic approach reveals brain-wide distribution and input connectivity of axo-axonic interneuron cells and establishes experimental access to study the circuit function of a ground truth cell type.
    1. Medicine

    Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study

    Ruijie Zeng, Yuying Ma ... Hao Chen
    Proton pump inhibitors are associated with an increased susceptibility to respiratory infections.
    1. Immunology and Inflammation
    2. Medicine

    Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

    Joanna C Porter, Jamie Inshaw ... Venizelos Papayannopoulos
    Nebulized dornase alfa endonuclease reduces inflammation, coagulopathy, and the length of hospitalization in individuals with severe COVID-19 pneumonia.
    1. Neuroscience

    How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

    Julia Ruge, Mana R Ehlers ... Tina B Lonsdorf
    Individuals with a history of adverse childhood experiences show blunted response to threat and reward irrespective of sample and paradigm characteristics and despite heterogeneity in adversity operationalization and assessment.
    1. Cell Biology
    2. Neuroscience

    Translational regulation enhances distinction of cell types in the nervous system

    Toshiharu Ichinose, Shu Kondo ... Hiromu Tanimoto
    Neuronal and glial cells in Drosophila differentiate the translation of neuronal mRNA with upstream open-reading frames.
    1. Neuroscience

    Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space

    Hyeri Hwang, Seung-Woo Jin, Inah Lee
    The intermediate region of the hippocampus is critical for strategic goal-directed navigation to the higher-value location, whereas the dorsal hippocampus implements the precise targeting of the goal location.
    1. Neuroscience

    Nonlinear sensitivity to acoustic context is a stable feature of neuronal responses to complex sounds in auditory cortex of awake mice

    Marios Akritas, Alex G Armstrong ... Jennifer F Linden
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing