Glucocorticoids are assumed to reflect 'stress,' but they increase proportionally to the increase in metabolic rate induced by stressors, leading us to propose that glucocorticoids reflect metabolic rate, not stress.
A common genetic variant in Black patients increases the risk of renal disease, which increases the risk of sepsis, but there is no direct association between the variant and sepsis.
Maria Ruesseler, Lilian Aline Weber ... Laurence Tudor Hunt
Human behaviour in a continuous decision making task adapts to the overall statistics of the sensory environment, and these adaptations are also reflected in changes in neural responses to incoming sensory evidence.
Isoform-specific variations in doublecortin-like kinases offer a new framework for understanding kinome-wide modulation of protein stability and catalytic activity.
The bicontinuous nanospheres platform enables dual encapsulation and in vivo activation of lipid and protein antigen-specific T cells, resulting in enduring lipid depots for sustained immune responses.
Tom G Richardson, Genevieve M Leyden, George Davey Smith
Leveraging time-varying and tissue-dependent genetic instruments into Mendelian randomization studies may help develop insight over more conventional applications.
Franziska Grathwol, Christian Roos ... Gisela H Kopp
The first sequenced mitogenome of a mummified non-human primate connects an Egyptian baboon dated to ca. 800–540 BCE to modern baboon populations in Eritrea, Ethiopia, and eastern Sudan, providing evidence for Egyptian–Adulite trade centuries earlier than current archaeological evidence.
A novel in vivo strategy for reversible, multiplexed control of circulating hormone expression levels, achieved by combining genome-editing and intramuscular electroporation of fluorescently tagged hormones in the naturally short-lived turquoise killifish.
Genetic analyses reveal the importance of dynamic protein processing at the apical cell membrane in response to forces damaging cell membranes during tube expansion in tubular organs.
