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An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.

SNARE protein tomosyn differentially affects two main secretory pathways in mammalian neurons.

Genetic interaction and biochemical analyses have unveiled the crucial involvement of CTPS in the regulation of adipocyte growth, lipid metabolism, and metabolic adaptation in Drosophila, achieved through activating the PI3K-Akt-SREBP pathway.

A rare population of endothelial cells emerges from a bipotent muscle progenitor population in the paraxial mesoderm and provides niche support to induce hematopoietic stem cells.

Single-cell transcriptomics enables functional dissection of signaling interactions that drive morphogenesis of complex organ systems.

SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.

Excitatory and inhibitory neurons in the mouse superior colliculus receive comparably strong inputs from retinal ganglion cells, in contrast to the thalamocortical system.

The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering with its antitumoral activity.

CaMKII and the actin-crosslinking protein α-actinin-2 associate within minutes of the induction of long-term potentiation and disrupting this interaction prevents formation of enlarged dendritic spines.

Quantification of both viral transcription and progeny production from single influenza-infected cells shows that the cells that produce the most viral RNA often do not produce the most virions.