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Leveraging the X-LD method for estimating inter-chromosomal linkage disequilibrium in the human genome uncovers a universal extended LD pattern, consistent with observations in 1KG cohorts.

Microtubules grow at highly variable rates, but they can be tightly coordinated merely by coupling their tips to a single shared load.

Biochemical and in vivo physiology imaging reveal that plant pathogens actively imbalance the apoplastic eAdo/eATP levels as a virulence mechanism.

p21-activated kinase 3 (PAK3) is a factor related to radiation-induced cognitive decline, and it has been found that regulating it leads to the recovery of cognitive decline induced by radiation.

Stereotactic body radiotherapy combined with immunotherapy and chemotherapy in neoadjuvant setting exhibited a promising anti-tumor activity and an acceptable safety profile in triple-negative breast cancer patients.

Using long-term in vivo imaging with miniature two-photon microscopy, microglia surveillance is sleep state-dependent and stress-induced in freely behaving mice, regulated by the locus coeruleus-norepinephrine system and β₂-adrenergic receptors signaling.

AlphaFold 2 models capture binding pocket structures accurately but fare poorly when used to predict ligand-binding poses.

The hadal snailfish rapidly evolved and adapted to extreme deep-sea environments, modifying crucial genes and enhancing tolerance to high-hydrostatic pressure through ferritin gene duplication.

Microglia differentially modulate the neuronal activities via P2Y12 and its downstream Ca²⁺ signaling in a brain region-specific manner, which facilitates and stabilizes the response to general anesthesia.

Preoptic area neurons co-expressing GABA and kisspeptin are essential for the preovulatory surge mechanism but not for the pulsatile secretion of luteinizing hormone.