Cancer Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

   Chiara Asselborn, Agata N Makar ... Alexander von Kriegsheim
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

   Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
3. 1. Cancer Biology

   Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma

   Gaoming Liao, Xinbin Yang ... Gang Xu

   BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8⁺ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4⁺ T differentiation.
4. 1. Cancer Biology
   2. Developmental Biology

   Tumors mimic the niche to inhibit neighboring stem cell differentiation

   Yang Zhang, Yuejia Wang ... Shaowei Zhao

   Drosophila female germline tumors mutant for bam or bgcn mimic the stem cell niche to inhibit the differentiation of neighboring wild-type germline stem cells.
5. 1. Cancer Biology

   Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

   Wanqiu Wang, Mengqi Yang ... Kun Sun
6. 1. Genetics and Genomics
   2. Cancer Biology

   Functional characterization of a multi-cancer risk locus on chromosome band 2q33.1 near CASP8

   Hyunkyung Kong, Jiyeon Choi ... Kevin M Brown
7. 1. Cancer Biology
   2. Cell Biology

   HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

   Sara M Frangos, Henver S Brunetta ... Graham P Holloway

   Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
8. 1. Cancer Biology
   2. Cell Biology

   Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

   David Papadopoli, Ranveer Palia ... Ivan Topisirovic

   Downregulation of the electron transfer flavoprotein dehydrogenase drives pro-tumorigenic metabolic programs via stimulating the mechanistic Target of Rapamycin Complex 1 signaling across a broad spectrum of cancers.
9. 1. Cancer Biology
   2. Microbiology and Infectious Disease

   RadD from Fusobacterium nucleatum engages NKp46 to promote antitumor cytotoxicity

   Ahmed Rishiq, Johanna Galaski ... Ofer Mandelboim

   RadD recognition by NKp46 converts Fusobacterium nucleatum from an immune-evasive pathogen into a trigger of natural killer cell-mediated tumor control in a context-dependent manner.
10. 1. Cancer Biology

    Integrated Human Transcriptomics Identifies Fallopian Tube Progenitors as Plausible Precursors of High-Grade Serous Ovarian Cancer

    Qian Li, Keren Cheng ... Wei Yan