Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Genetics and Genomics

   Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

   Ting Zhang, Alisa Ambrodji ... Steven M Offer

   A genetic variant within a newly identified enhancer regulates the expression of a key pharmacogene and alters the balance between resistance and sensitivity to a widely used chemotherapeutic.
2. 1. Cancer Biology
   2. Epidemiology and Global Health

   Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study

   Lijun Bian, Zhimin Ma ... Guangfu Jin

   Older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle.
3. 1. Cancer Biology
   2. Cell Biology

   Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

   Timothy J Walker, Eduardo Reyes-Alvarez ... Lois M Mulligan

   TMEM127 depletion alters membrane dynamics, promoting cell surface accumulation and constitutive activity of growth factor receptors, and ultimately providing a novel paradigm for oncogenesis through aberrant receptor localization and signaling.
4. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

   Gregory Caleb Howard, Jing Wang ... William P Tansey

   Analysis of the action of WDR5 inhibitors in leukemia cells reveals decreased ribosome inventory, impaired protein synthesis, induction of nucleolar stress, and activation of p53 via alternative splicing of MDM4.
5. 1. Cancer Biology
   2. Cell Biology

   N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion

   Julian JA Hoving, Elizabeth Harford-Wright ... Alison C Lloyd

   N-cadherin and Slit2/3/Robo interactions provide the outward force to drive collective Schwann cell migration during nerve regeneration, identifying a dual role for N-cadherin in both adhesion and repulsion processes during Schwann cell collective migration.
6. 1. Cancer Biology

   Recording and classifying MET receptor mutations in cancers

   Célia Guérin, David Tulasne

   Classification of MET mutations allows a better understanding of sensitivity and resistance to targeted therapies used in cancer.
7. 1. Cancer Biology
   2. Genetics and Genomics

   Convergent epigenetic evolution drives relapse in acute myeloid leukemia

   Kevin Nuno, Armon Azizi ... Ravindra Majeti

   Integrated analyses of acute myeloid leukemia genetics and epigenetics demonstrate that epigenetic evolution occurs in a convergent manner in the absence of DNA mutations at relapse post-chemotherapy.
8. 1. Medicine
   2. Cancer Biology

   RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

   Yang Liu, Yi Jiang ... Xi Gu
9. 1. Cancer Biology

   Overcoming the nutritional immunity by engineering iron scavenging bacteria for cancer therapy

   Sin-Wei Huang, See-Khai Lim ... Kurt Yun Mou
10. 1. Cell Biology
    2. Cancer Biology

    Automated workflow for the cell cycle analysis of non-adherent and adherent cells using a machine learning approach

    Kourosh Hayatigolkhatmi, Chiara Soriani ... Simona Rodighiero