Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

   Zijing Wang, Bihan Xia ... Jilin Yang

   The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
2. 1. Cancer Biology

   A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer

   Bruno Bockorny, Lakshmi Muthuswamy ... Senthil K Muthuswamy

   Proteomic profiling of extracellular vesicle proteins from patients with benign and malignant pancreatic diseases offers a valuable resource for identifying biomarkers for pancreatic cancer detection.
3. 1. Cancer Biology
   2. Evolutionary Biology

   The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)

   Lingjie Zhang, Tong Deng ... Chung-I Wu

   A mathematical model shows that mutations that recur even modestly among cancer patients are cancer driving nucleotides that can be exhaustively identified to serve as targets of cancer therapy.
4. 1. Cancer Biology
   2. Evolutionary Biology

   Characterization of cancer-driving nucleotides (CDNs) across genes, cancer types, and patients

   Lingjie Zhang, Tong Deng ... Hai-Jun Wen

   Analyses of discovered cancer-driving nucleotides (CDNs) reveal their evolutionary, biochemical, and therapeutic characteristics that are often shared among multiple cancer types.
5. 1. Cancer Biology
   2. Genetics and Genomics

   Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

   Yaroslav Kainov, Fursham Hamid, Eugene V Makeyev

   Somatic mutations frequently disrupt cleavage and polyadenylation signals in tumour suppressor genes in human cancers, likely contributing to tumour progression.
6. 1. Cancer Biology
   2. Immunology and Inflammation

   Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

   Simei Go, Constantinos Demetriou ... Eric O Neill

   Tissue-resident natural killer cells are important mediators of CD8 T responses in human cancers and these cells can be harnessed to increase immunity against pancreatic ductal adenocarcinoma.
7. 1. Cancer Biology

   S100a4⁺ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting fatty acid metabolism

   Hong Huang, Ying Yang ... Le Zhang
8. 1. Cancer Biology

   Increased inflammatory signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden

   Hyungtai Sim, Hyun Jung Park ... Murim Choi

   In metastatic NSCLC patients, CHIP showed minimal impact on immunotherapy response but was more prevalent and associated with inflammatory pathways in myeloid cells, particularly in lung squamous cell carcinoma.
9. 1. Cancer Biology

   Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

   Yu-Chia Chen, Mamoru Takada ... Aussie Suzuki
10. 1. Microbiology and Infectious Disease
    2. Cancer Biology

    The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling and phosphorylation of Akt and Erk in HPV16-infected cervical cancer

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng