Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   Chemotherapy: Lipid balance and chemoresistance in cancer cells

   Kaori Kanemaru, Yoshikazu Nakamura

   A shift in the balance between two lipids – cholesterol and sphingomyelin – makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.
2. 1. Cancer Biology
   2. Genetics and Genomics

   Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

   Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang

   A replication stress–ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.
3. 1. Cancer Biology

   Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

   Kyle Spinler, Michael Hamilton ... Tannishtha Reya

   A naturally occurring Musashi2 genetic translocation reported to occur in blast crisis chronic myelogenous leukemia patients can act as an oncogene and drive myeloid leukemia.
4. 1. Cancer Biology

   Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

   Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk

   Transcriptomic and metabolite analysis reveal sex differences in circulation and excretion of bile acids in a mouse- model of hepatocellular carcinoma (HCC), and the identified female-specific gene profile correlates with better HCC survival.
5. 1. Cancer Biology

   Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

   Jessica Armand, Sungsoo Kim ... Hee Won Yang

   Maintaining CDK4/6 inhibition constrains drug‑resistant breast tumors by delaying cell‑cycle entry, and adding CDK2 inhibition further deepens control to guide post‑progression therapy.
6. 1. Cancer Biology

   Breast Cancer: Slowing the growth of drug-resistant tumors

   Yingyi Zhang, Qianying Lu

   Using drugs that inhibit enzymes called CDK4/6 and CDK2 extends the G1 phase of the cell cycle and helps to slow the growth of drug-resistant breast cancer.
7. 1. Cell Biology
   2. Cancer Biology

   GMCL1 Controls 53BP1 Stability and Modulates Taxane Sensitivity

   Yuki Kito, Tania J González-Robles ... Michele Pagano
8. 1. Cancer Biology

   Multi-gradient permutation survival analysis identifies mitosis and immune signatures steadily associated with cancer patient prognosis

   Xinlei Cai, Yi Ye ... Hongbin Ji

   Genes steadily associated with prognosis define conserved mitotic and immune programs that robustly predict cancer patient survival and therapeutic resistance across tumor types.
9. 1. Cancer Biology

   Endoscopic liquid biopsies of gastric fluid in a large human patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer

   Francine C Cadoná, Thais F Bartelli ... Emmanuel Dias-Neto

   Elevated gfDNA supports gastric cancer diagnosis and may guide management when combined with tissue biopsies, and in established cancer, higher gfDNA may predict better outcomes, potentially indicating immune-cell infiltration.
10. 1. Cancer Biology

    Transcriptional subtypes on immune microenvironment and predicting postoperative recurrence and metastasis in human pheochromocytoma and paraganglioma

    Yang Liu, Xu Yan ... Lingyu Li

    Distinct transcriptional subtypes in PPGLs link molecular programs with immune context, providing biomarkers for recurrence risk and therapeutic targeting.