Cancer Biology

Latest articles

1. 1. Cancer Biology

   PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

   Samarjit Jana, Mainak Mondal ... Kumaravel Somasundaram

   PITAR interaction with TRIM28 mRNA, which encodes a p53 targeting E3 ubiquitin ligase, keeps p53 levels low for cancer cells to divide and attenuates the DNA damage response by p53.
2. 1. Cancer Biology
   2. Neuroscience

   Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

   Jeffrey Barr, Austin Walz ... Paola D Vermeer

   Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
3. 1. Cancer Biology

   Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

   Anne Fajac, Iva Simeonova ... Franck Toledo

   The male-specific tumor-suppressive effects of minor p53 isoforms were correlated with higher Ackr4 expression levels, which have implications for sex-specific cancer prognosis in humans.
4. 1. Cell Biology
   2. Cancer Biology

   TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

   Maojin Tian, Le Yang ... Peiqing Zhao
5. 1. Cancer Biology

   Engineering PEG10-assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

   Ruijing Tang, Luobin Guo ... Xiaolong Liu

   ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
6. 1. Cancer Biology
   2. Structural Biology and Molecular Biophysics

   Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

   Gabriella O Estevam, Edmond M Linossi ... James S Fraser

   Deep mutational scanning reveals interactions in the MET kinase domain that are critical for regulation and cancer-related signaling.
7. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

   Alison G Barber, Cynthia M Quintero ... Tannishtha Reya
8. 1. Medicine
   2. Cancer Biology

   Development and Assessment of a Sustainable PhD Internship Program Supporting Diverse Biomedical Career Outcomes

   Patrick D Brandt, Dawayne Whittington ... Rebekah L Layton
9. 1. Cancer Biology

   The T Cell Receptor β Chain Repertoire of Tumor Infiltrating Lymphocytes Improves Neoantigen Prediction and Prioritization

   Thi Mong Quynh Pham, Thanh Nhan Nguyen ... Le Son Tran
10. 1. Cancer Biology

    Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

    Elazar Besser, Anat Gelfand ... David Meiri

    The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.