Cancer Biology

Latest articles

1. 1. Developmental Biology
   2. Cancer Biology

   Tumors mimic the niche to inhibit neighboring stem cell differentiation

   Yang Zhang, Yuejia Wang ... Shaowei Zhao
2. 1. Cancer Biology
   2. Cell Biology

   Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

   Qi Zhang, Yunfeng Wang ... Shaowei Zhao

   Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
3. 1. Cancer Biology
   2. Immunology and Inflammation

   The 1000⁺ mouse project for large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

   Adam L Kenet, Sooraj Achar ... Grégoire Y Altan-Bonnet

   An automated bioluminescent image analysis framework, maRQup, parametrizes tumor dynamics and provides quantitative metrics, enabling large-scale evaluation and optimization of preclinical cancer immunotherapies.
4. 1. Cancer Biology

   Design of combination therapeutics from protein response to drugs in ovarian cancer cells

   Alexandra Franz, Ciyue Shen ... Chris Sander
5. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   In vitro reconstitutions suggest a general model for paradoxical activation of ARAF, BRAF, and CRAF by diverse RAF inhibitor types that does not rely on negative allostery

   Emre Tkacik, Dong Man Jang ... Michael J Eck
6. 1. Cancer Biology

   Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer

   Yue Zhang, Hanbing Wang ... Yue Wang

   Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor immunity.
7. 1. Computational and Systems Biology
   2. Cancer Biology

   Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

   Anthony Hart, Sung-Young Shin, Lan K Nguyen
8. 1. Cancer Biology

   Turning aging cells into a live vaccine: engineered senescent cancer cells with adjuvant celecoxib for immunotherapy

   Yuewei Wang, Ante Ou ... Yongzhuo Huang
9. 1. Cancer Biology

   Nerve Injury-Induced Protein 2 preserves lysosomal membrane integrity to suppress ferroptosis

   Jin Zhang, Miranda Bustamante ... Xinbin Chen
10. 1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal

    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.