Cell Biology

Latest articles

1. 1. Cell Biology

   Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes

   Hideyuki Shimizu, Martin Baron
2. 1. Cancer Biology
   2. Cell Biology

   HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

   Sara M Frangos, Henver S Brunetta ... Graham P Holloway

   Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
3. 1. Cell Biology
   2. Computational and Systems Biology

   Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics

   Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
4. 1. Cell Biology

   An ancient transcription factor functions as the master regulator of primary cilia formation

   Weihua Wang, Xiqi Zhang ... Zhangfeng Hu
5. 1. Cancer Biology
   2. Cell Biology

   Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

   David Papadopoli, Ranveer Palia ... Ivan Topisirovic

   Downregulation of the electron transfer flavoprotein dehydrogenase drives pro-tumorigenic metabolic programs via stimulating the mechanistic Target of Rapamycin Complex 1 signaling across a broad spectrum of cancers.
6. 1. Cell Biology

   The FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle

   Taylar Hammond, Jong Bin Choi ... Julien Sage

   The poorly characterized FAM53C protein is an inhibitor of the DYRK1A kinase and governs the G1/S transition of the cell cycle.
7. 1. Cell Biology
   2. Developmental Biology

   Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension in Xenopus

   Hwa-seon Seo, Deli Yu ... Jianbo Wang

   During convergent extension morphogenesis, non-canonical Wnt induces the signal transducer Dishevelled to transition from Vangl to Frizzled, a process that is inhibited by Prickle but facilitated by the co-receptor Ror.
8. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Unbend, correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

   Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff

   Movie alignment software uses a 3D spline model to capture beam-induced motion in cryo-electron microscopy movie frames, correct local sample distortions, and improve two-dimensional template matching signal-to-noise ratios in the corrected images.
9. 1. Cell Biology

   Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

   Jing-Xin Feng, Mei-Ting Yang ... Giovanna Tosato

   Single-cell and bulk lineage tracing reveals that adult bone marrow endothelial cells generate functional hematopoietic progenitor and mature blood cells, expanding the cell sources of postnatal hematopoiesis.
10. 1. Cell Biology

    Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

    Qiwang Xiang, Camille Wouters ... Jiou Wang