Cell Biology

Latest articles

1. 1. Cell Biology
   2. Neuroscience

   Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila

   Francisco Muñoz-Carvajal, Nicole Sanhueza ... Felipe A Court

   Age-related epigenetic regulation of mitochondrial stress responses drives neuronal degeneration and sensory decline, highlighting mitochondrial resilience as a potential target to preserve brain function during aging.
2. 1. Cell Biology
   2. Physics of Living Systems

   Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction

   Daniel Haertter, Lara Hauke ... Christoph F Schmidt
3. 1. Cell Biology
   2. Developmental Biology

   A novel 3D visualization method in mice identifies the periportal lamellar complex (PLC) as a key regulator of hepatic ductal and neuronal branching morphogenesis

   Tongtong Xu, Fujun Cao ... Chengjian Zhao

   A high-resolution 3D imaging platform reveals the periportal lamellar complex as a novel structural feature in the mouse liver, regulating bile duct and nerve migration during fibrosis.
4. 1. Cell Biology

   Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes

   Hideyuki Shimizu, Martin Baron
5. 1. Cancer Biology
   2. Cell Biology

   HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

   Sara M Frangos, Henver S Brunetta ... Graham P Holloway

   Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
6. 1. Cell Biology
   2. Computational and Systems Biology

   Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics

   Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
7. 1. Cell Biology

   An ancient transcription factor functions as the master regulator of primary cilia formation

   Weihua Wang, Xiqi Zhang ... Zhangfeng Hu
8. 1. Cancer Biology
   2. Cell Biology

   Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

   David Papadopoli, Ranveer Palia ... Ivan Topisirovic

   Downregulation of the electron transfer flavoprotein dehydrogenase drives pro-tumorigenic metabolic programs via stimulating the mechanistic Target of Rapamycin Complex 1 signaling across a broad spectrum of cancers.
9. 1. Cell Biology

   The FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle

   Taylar Hammond, Jong Bin Choi ... Julien Sage

   The poorly characterized FAM53C protein is an inhibitor of the DYRK1A kinase and governs the G1/S transition of the cell cycle.
10. 1. Cell Biology
    2. Developmental Biology

    Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension in Xenopus

    Hwa-seon Seo, Deli Yu ... Jianbo Wang

    During convergent extension morphogenesis, non-canonical Wnt induces the signal transducer Dishevelled to transition from Vangl to Frizzled, a process that is inhibited by Prickle but facilitated by the co-receptor Ror.